Patent classifications
C
C12
C12N
2760/00
C12N2760/00011
C12N2760/18011
C12N2760/18711
C12N2760/18751
C12N2760/18752
C12N2760/18752
Engineered cells with decreased gene expression resulting in increased viral production
Disclosed are compositions and methods for increasing virus production. In particular, disclosed herein are cell or cell line comprises reduced expression of one or more cellular genes selected from the group comprising COQ9, FGF2, NAT9, NDUFA9, NEU2, PLA2G1B, PYCR1, RAD51AP1, STRADA, SVOPL, and/or ZFYVE9 for use in increasing viral production.
METHODS AND COMPOSITIONS RELATED TO INCREASED VIRAL PRODUCTION
Disclosed are compositions and methods for increasing virus production.
METHOD OF PRODUCING NEGATIVE-STRAND RNA VIRUS VECTOR AND PRODUCED NEGATIVE-STRAND RNA VIRUS VECTOR
The present disclosure provides a method of producing a negative-strand RNA virus vector. The present disclosure specifically provides a method of producing a negative-strand RNA virus vector in the presence of a PKR inhibitory factor.