A method of treating cancer in a subject in need thereof includes administering in situ to the cancer a therapeutically effective amount of a virus or virus-like particle.

The present disclosure provides new attenuated Pepino mosaic viruses useful in the control of plant disease. Compositions for biological control of plant disease are also provided as well as methods for producing Pepino mosaic virus resistant plants.

A method of treating cancer in a subject in need thereof includes administering in situ to the cancer a therapeutically effective amount of a virus or virus-like particle.

A method of treating cancer in a subject in need thereof includes administering in situ to the cancer a therapeutically effective amount of a virus or virus-like particle.

The present disclosure provides new attenuated Pepino mosaic viruses useful in the control of plant disease. Compositions for biological control of plant disease are also provided as well as methods for producing Pepino mosaic virus resistant plants.

A method of treating cancer in a subject in need thereof includes administering in situ to the cancer a therapeutically effective amount of a virus or virus-like particle.

An intratumoral immunotherapy for treating cancer in a subject in need includes a therapeutically effective amounts of cowpea mosaic virus (CPMV), CPMV virus-like particles, potato virus X (PVX), and/or PVX virus-like particles formulated for in situ administration to cancer of the subject, wherein the therapeutically effective amount of CPMV, CPMV virus-like particles, PVX, and/or PVX virus-like particles is an amount effective to provide a durable and systemic anticancer response against cancer metastasis and recurrence in the subject, and the CPMV, CPMV virus-like particles, PVX, and/or PVX virus-like particles are not used as a vehicle for drug or antigen delivery.