Methods of using fibrillar proteins are provided for suppressing cancer metastasis. Cancer metastasis is the most common cause of treatment failure and death in cancer patients. Tumor cell invasion and/or migration can be significantly inhibited after fibrillar proteins (rVP1, F-HSA, and F-BSA) treatment in vitro. In addition, rVP1 can significantly suppress murine and human breast cancer metastasis and human prostate and ovarian cancer metastasis in vivo while F-HSA can significantly suppress murine breast cancer metastasis.

Provided herein are immunoresponsive cells expressing a MUC1 targeting pCAR comprising a second generation chimeric antigen receptor (CAR) and a chimeric co-stimulatory receptor (CCR). Also provided herein are methods of preparing the immunoresponsive cells and methods of directing T cell mediated immune response using the immunoresponsive cells.

Embodiments of the claimed invention are directed to synthetic peptides comprising an amino acid sequence of X.sub.1X.sub.2VX.sub.3NLRGDLQVLX.sub.4QKVCX.sub.5T (SEQ ID NO:18), wherein at least one of X.sub.1 and X.sub.2 is a cysteine, and wherein one or more of X.sub.3, X.sub.4, and X.sub.5 is a non-natural amino acid. Also described are methods of using the claimed embodiments for inhibiting growth of a cancer cell overexpressing integrin ?v?6. Additionally, also described are methods of using the claimed embodiments for detecting a cancer cell overexpressing integrin ?v?6.