Patent classifications
C
CHEMISTRY; METALLURGY
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C12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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C12N
MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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C12N2770/32341
Use of virus, viral particle or viral elements as a vector
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C12N2770/32345
Special targeting system for viral vectors
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C12N2770/32345

MIR-375- AND MIR-1-REGULATED COXSACKIEVIRUS B3 HAS NO PANCREAS AND HEART TOXICITY BUT STRONG ANTITUMOR EFFICIENCY IN COLORECTAL CARCINOMAS
20240252564 · 2024-08-01 ·

The present invention related to an infectious complementary DNA (cDNA) construct characterized in that the cDNA comprises: the cDNA of the CVB3 genomic RNA sequence of a Coxsackievirus B3 (CVB3); at least one or more microRNA target sequences (miR-TS), which are complementary to one or more microRNAs having tissue-specific expression pattern, wherein the at least one or more miR-TS are integrated immediately adjacent of the 5UTR and/or the 3UTR of the CVB3 protein coding sequence.