Patent classifications
C
CHEMISTRY; METALLURGY
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C12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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C12N
MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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C12N2770/36211
Rubivirus, e.g. rubella virus
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C12N2770/36241
Use of virus, viral particle or viral elements as a vector
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C12N2770/36244
Chimeric viral vector comprising heterologous viral elements for production of another viral vector
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C12N2770/36244

FLEXIBLE EXPRESSION VECTOR SYSTEMS AND APPLICATION OF SAME TO VACCINES AND IMMUNOTHERAPEUTICS
20240254515 · 2024-08-01 · ·

The present invention relates to an expression vector that encodes all or a portion of replicon proteins from a positive stranded virus, wherein expression of the replicon proteins is under the control of CMV and T7 promoters, and wherein expression of a payload is under the control of a sub-genomic promoter. Also provided are methods of using the vector in therapeutics and vaccines.