C12P17/183

POLYNUCLEOTIDES, POLYPEPTIDES, RECOMBINANT CELLS AND METHODS FOR GENERATING ERGOLINES AND PRECURSORS AND METABOLITES THEREOF

Provided are non-naturally occurring polynucleotide sequences that encode for polypeptides useful in ergoline biosynthesis, as well as the non-naturally occurring polypeptide sequences. Also provided are recombinant host cell and methods for microbial biosynthesis of an ergoline, or a precursor or metabolite thereof, using the recombinant host cell.

Enzymes for transforming ergopeptines and method therefor

Enzymes for transforming, in particular hydrolytically cleaving, ergopeptines, which ergopeptines are /-hydrolases hydrolytically cleaving ergopeptines in the cyclol ring, for the transformation of ergopeptines, and method for producing ergopeptine-metabolizing enzymes.