Transgenic seed for crops with improved traits are provided by trait-improving recombinant DNA where plants grown from such transgenic seed exhibit one or more improved traits as compared to a control plant. Exemplary recombinant DNA expresses a succinate semialdehyde dehydrogenase.

Transgenic seed for crops with improved traits are provided by trait-improving recombinant DNA where plants grown from such transgenic seed exhibit one or more improved traits as compared to a control plant. Also provided are methods of making transgenic plants with recombinant DNA and the one or more improved traits and methods of using those plants.

Provided herein are methods and compositions for treating succinic semialdehyde dehydrogenase deficiency (SSADHD) using gene therapy to restore, at least partially, expression and/or activity of succinic semialdehyde dehydrogenase (SSADH).