An object is to provide a composition and a method for eliminating undifferentiated pluripotent stem cells remaining in a cell group induced to differentiate from pluripotent stem cells. It has been found that while dihydroorotate dehydrogenase inhibitors exhibit cytotoxic activity against pluripotent stem cells, they do not exhibit significant cytotoxic activity against differentiated cells such as somatic stem cells.

A therapeutic composition includes a mother tincture of a leaf extract of a plant of the genus Neurolaena and the species lobata for use as a drug inhibiting human dihydroorotate dehydrogenase (DHODH).