A novel technique for reducing the mis-cleavage of the TorA signal peptide, and thereby a method for efficient secretory production of a heterologous protein by a coryneform bacterium using a TorA signal peptide is provided. A coryneform bacterium having an ability of secretory production of a heterologous protein using a TorA signal peptide and has been modified so that the activity of a LepB protein is increased is cultured to produce the heterologous protein by secretory production.

The present invention provides a Paracoccus aminovorans BM109 strain (Accession number KCTC 15059BP) having excellent removal of trimethylamine (TMA) or trimethylamine N-oxide (TMAO), and a pharmaceutical composition for preventing or treating diseases caused by TMA or TMAO, a health functional food composition for preventing or improving diseases caused by TMA or TMAO, and a feed composition for preventing or improving diseases caused by TMA or TMAO, including the strain as an active ingredient.