Methods and fluid compositions are provided for decreasing an amount of sulfur-containing compounds in downhole fluids and/or subterranean reservoir wellbores by including at least one enzyme destabilizer in a fluid composition. The fluid composition may then be circulated into a subterranean reservoir wellbore. The fluid composition may further include a base fluid and at least one sulfur producing enzyme. The base fluid may be or include, but is not limited to, drilling fluids, servicing fluids, production fluids, completion fluids, injection fluids, refinery fluids, and combinations thereof. The enzyme destabilizer(s) may be destabilize the sulfur producing enzymes and thereby decrease an amount of sulfur-containing compounds produced vis-à-vis the sulfur producing enzyme(s).

The present invention relates, in part, to treatment of various diseases and disorders such as GI disorders through modulation of F420-dependent enzymes including specific enzymes involved in methanogenesis.