The present disclosure relates to a marker for diagnosing neurodegenerative diseases, and a use thereof, and, more particularly, to: a marker composition for diagnosing neurodegenerative diseases; a composition for diagnosing neurodegenerative diseases, containing a preparation for measuring the glutathionylation level of a FUS protein; a kit for diagnosing neurodegenerative diseases, containing the composition; and an information providing method for diagnosing neurodegenerative diseases by using same. The inventors have discovered that a glutathionylated FUS protein functions as a marker for diagnosing neurodegenerative diseases, and thus a composition for diagnosing neurodegenerative diseases, according to the present disclosure, is expected to contribute to early diagnosis of patients with neurodegenerative diseases.

In addition, the present disclosure identifies GSTO1 or GstO2, which is a factor inducing the deglutathionylation of a FUS protein, so as to ascertain effects of inhibiting brain cytoplasmic aggregation and neurocytotoxicity by using same, and thus is expected to be effectively used for preventing, treating or alleviating neurodegenerative diseases.