The invention relates to production of polyamine analogs in yeast cells that are capable of producing at least one polyamine. The yeast cells also comprise a 4-coumarate:CoA ligase encoding gene, at least one polyamine N-acyltransferase gene and at least one polyamine synthase encoding gene but lacks a polyamine oxidase encoding gene or comprises a disrupted polyamine oxidase encoding gene. The yeast cells are capable of producing mono- and/or multi-substituted N-acylated polyamines.

The invention relates to production of polyamine conjugates in yeast cells that are capable of producing at least one polyamine. The yeast cells also comprise a polyamine:glutathione ligase encoding gene and at least one polyamine synthase encoding gene but lacks a polyamine oxidase encoding gene or comprises a disrupted polyamine oxidase encoding gene. The yeast cells are capable of producing various polyamine-glutathione conjugates.