The present invention provides proline specific endopeptidases. The present invention further provides methods for use of proline specific endopeptidases for use in reduction of chill haze in a beverage, including beer. The present invention further provides methods for producing protein hydrolysates using proline specific endopeptidases. Also provided are methods of treating disease, including Celiac disease using proline specific endopeptidases. Also provided are nucleic acids encoding the proline specific endopeptidases and host cells for production of the proline specific endopeptidases.

Compositions having at least one compound which inhibits the formation of Hemipteran stylet sheaths and/or degrades hemipteran style sheaths that have already been formed, and thus deters or blocks hemipteran insects from feeding on plants, especially agriculturally important plants and methods of use of such compositions are described. Such compositions can be applied onto plants by spraying, dripping, or other methods and/or can be applied to the soil for uptake by the roots. These compositions and methods prevent and/or reduce the transmission of vascular associated diseases (caused by hemipteran vector-borne pathogens) to plants.

Compositions having at least one compound which inhibits the formation of Hemipteran stylet sheaths and/or degrades hemipteran style sheaths that have already been formed, and thus deters or blocks hemipteran insects from feeding on plants, especially agriculturally important plants and methods of use of such compositions are described. Such compositions can be applied onto plants by spraying, dripping, or other methods and/or can be applied to the soil for uptake by the roots. These compositions and methods prevent and/or reduce the transmission of vascular associated diseases (caused by hemipteran vector-borne pathogens) to plants.

Disclosed herein is a recombinant viral vector comprising an AAV 5 inverted terminal repeat (ITR) sequence, an AAV 3 ITR sequence, and an expression cassette flanked by the AAV 5 ITR and 3 ITR sequences. According to the embodiments of the present disclosure, the expression cassette comprises a first and a second coding sequences respectively encoding a human neuraminidase 1 (NEU1) and a human protective protein/cathepsin A (PPCA). Also disclosed herein are a recombinant adeno-associated virus (AAV) comprising the recombinant viral vector, a pharmaceutical composition comprising the recombinant AAV, and uses thereof in treating sialidosis.