Cleaning compositions may include a mix of enzymes that include a mix of enzymes. Said compositions may be used in cleaning processes and/or for deep cleaning of organic stains, and for removal or reduction of components of organic matter.

The present disclosure relates to serine proteases and variants thereof. Compositions containing the serine proteases are suitable for use in cleaning fabrics and hard surfaces, as well as in a variety of industrial applications.

The present invention relates to methods and kits for detecting in a sample the presence of a virus particle or a virus-like particle that has reverse transcriptase activity and methods for preparing a retroviral contaminant-free substance. An aspect of the present invention is a method for detecting the presence of a virus particle in a sample of a Virus-like Particle (VLP) drug substance comprising a step of performing PCR-based reverse transcriptase (PBRT) on a sample of the VLP drug substance that has been treated with a protease.

The present invention provides a process for the preparation of tofacitinib citrate of Formula I. Specifically, the present invention provides an enzymatic route for the preparation of tofacitinib of Formula II, which is converted to tofacitinib citrate of Formula I.

Disclosed herein are compositions including (A) at least one polymer including (a) a core obtained by reacting a diamine H.sub.2N—Z—NH.sub.2 with a compound having a total number TN of carboxyl groups per molecule in the range of from 3 to 10, where Z is selected from C.sub.3-C.sub.12-cycloalkylene that may be non-substituted or substituted with one or more O—C.sub.1-C.sub.4-alkyl groups and where C.sub.3-C.sub.12-cycloalkylene may bear one to three methyl groups, and where carboxyl groups are selected from COOH and COOX.sup.1 with X.sup.1 being selected from C.sub.1-C.sub.4-alkyl, or two carboxyl groups together form an anhydride group, (b) polyalkylene oxide chains, and (B) at least one hydrolase.

Disclosed is a method for recovering a desired fermentation product from a fermentation broth where the desired product has precipitated during the fermentation.

The disclosure provides for artificial signal peptides generated by systems and methods utilizing deep learning.

The present invention relates to protease variants and methods for obtaining protease variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.

Disclosed herein is one or more subtilisin variant, nucleic acid encoding same, and compositions and methods related to the production and use thereof, including one or more subtilisin variant that has improved stability compared to one or more reference subtilisin.

The present invention relates to a method for obtaining chitin and/or chitosan from insect cuticles. More particularly, the method according to the present invention comprises a first enzymatic hydrolysis of insect cuticles using at least one endopeptidase, separation from the hydrolysis medium of the hydrolyzed cuticles resulting from the first enzymatic hydrolysis, and a second enzymatic hydrolysis of the hydrolyzed cuticles using at least one endopeptidase, excluding exopeptidase.