The present invention relates to a novel endoprotease, mutants thereof having binding but lacking or having reduced hydrolyzing activity, and use in methods of studying and isolating O-linked glycoproteins.

The present invention relates to a novel endoprotease, mutants thereof having binding but lacking or having reduced hydrolyzing activity, and use in methods of studying and isolating O-linked glycoproteins.

The present invention relates to a novel endoprotease, mutants thereof having binding but lacking or having reduced hydrolyzing activity, and use in methods of studying and isolating O-linked glycoproteins.

The present invention relates to enzymes and combinations thereof useful for studying glycoproteins, and corresponding methods of use. In particular, the invention relates to a sialidase composition comprising an additional protease and/or glycosidase, preferably an O-glycoprotein-specific endoprotease and/or an O-glycosidase.

A method of promoting a desired oral microbiota to treat an inflammation condition related to an allergic reaction in a subject in need of such treatment including providing a preformulated edible composition including an amino acid containing ingredient comprising L-arginine, the composition configured to be present as individual molecules of L-arginine within an oral cavity of the subject; removing a biofilm from surfaces within an oral cavity including exposing the biofilm to a biofilm degrading enzyme; wherein during or following removal of the biofilm, the composition is provided contained and at least partially dissolved within an oral cavity of the subject for a period of at least from about 30 seconds to about an hour on a daily basis comprising at least one day to promote an increased concentration of selected oral microbiota, the selected microbiota including Veillonella and Streptococcus.

A method of promoting a desired oral microbiota to treat an inflammation condition related to an allergic reaction in a subject in need of such treatment including providing a preformulated edible composition including an amino acid containing ingredient comprising L-arginine, the composition configured to be present as individual molecules of L-arginine within an oral cavity of the subject; removing a biofilm from surfaces within an oral cavity including exposing the biofilm to a biofilm degrading enzyme; wherein during or following removal of the biofilm, the composition is provided contained and at least partially dissolved within an oral cavity of the subject for a period of at least from about 30 seconds to about an hour on a daily basis comprising at least one day to promote an increased concentration of selected oral microbiota, the selected microbiota including Veillonella and Streptococcus.

Disclosed are compositions and methods involving proteases specific for mannose-modified proteins. The compositions and methods are particularly useful for making linker-specific cleavages in proteins produced by yeast and fungal cells. One use of the compositions and methods is for agglomerating yeast and yeast components in fermentation products. Another use of the composition is for producing a fraction of protein with reduced carbohydrate content.

The present invention relates to enzymes and combinations thereof useful for studying glycoproteins, and corresponding methods of use. In particular, the invention relates to a sialidase composition comprising an additional protease and/or glycosidase, preferably an O-glycoprotein-specific endoprotease and/or an O-glycosidase.

The present invention relates to a novel endoprotease, mutants thereof having binding but lacking or having reduced hydrolyzing activity, and use in methods of studying and isolating O-linked glycoproteins.