Patent classifications
C12Y304/2408
Bicyclic peptide ligands and uses thereof
The present invention provides compounds, compositions thereof, and methods of using the same.
SYNTHESIS OF BICYCLE TOXIN CONJUGATES, AND INTERMEDIATES THEREOF
The present invention relates to Bicycle toxin conjugates, methods for preparation, and methods of use for treating cancer.
Nanoparticles Having Molecules That Bind or Block PD-L1 and Uses In Treating Cancer
This disclosure relates to peptides and nanoparticles comprising a surface molecule that binds or blocks PD-L1. In certain embodiments, the disclosure relates to methods of using peptides or nanoparticles disclosed herein for the treatment of cancer. In certain embodiments, the disclosure relates to methods of using nanoparticles disclosed herein for therapeutic and diagnostic applications.
FIBROSIS-INHIBITING COMPOSITION, CELLS PRODUCING SAME, AND CELL SHEET COMPRISING SAID CELLS
[Problem] To provide a composition and a cell sheet which are highly effective for inhibiting fibrosis, or cells having fibrosis-inhibiting activity, which are useful in regenerative medicine. [Solution] A medium containing IC-2 or a related compound is inoculated with mesenchymal stem cells or bone marrow mononuclear cells, and the cells are cultured for a prescribed period of time while the IC-2 or related compound is maintained at a constant concentration, thereby allowing a composition and a cell sheet which are highly effective for inhibiting fibrosis, or cultured cells having fibrosis-inhibiting activity, to be obtained.
BICYCLIC PEPTIDE LIGANDS AND USES THEREOF
The present invention provides compounds, compositions thereof, and methods of using the same.
Bicyclic peptide ligands and uses thereof
The present invention provides compounds, compositions thereof, and methods of using the same.
METHODS AND COMPOSITIONS FOR REDUCING CARDIAC DAMAGE AND OTHER CONDITIONS
Endoglin has been identified to play a functional role as a regulator of TGF1 signaling, particular in TGF1-mediated calcineurin expression. The present invention features methods of reducing cardiac damage, particularly in a subject undergoing chemotherapy or radiation therapy by administering a composition that inhibits endoglin activity. The present invention also features methods of treating autoimmune diseases, inflammatory diseases, organ transplantation, and conditions association with oxidative stress related to TGF1-mediated calcineurin expression and reactive oxygen species (ROS) production by administering a composition that inhibits endoglin activity. The present invention also features methods of treating fibrotic diseases by administering a composition that inhibits endoglin activity.
Nanoparticles Having Molecules That Bind or Block PD-L1 and Uses In Treating Cancer
This disclosure relates to nanoparticles comprising a surface molecule that binds or blocks PD-L1. In certain embodiments, the disclosure relates to methods of using peptides or nanoparticles disclosed herein for the treatment of cancer. In certain embodiments, the disclosure relates to methods of using nanoparticles disclosed herein for therapeutic and diagnostic applications.
BICYCLIC PEPTIDE LIGANDS AND USES THEREOF
The present invention provides compounds, compositions thereof, and methods of using the same.
Nanoparticles having molecules that bind or block PD-L1 and uses in treating cancer
This disclosure relates to peptides and nanoparticles comprising a surface molecule that binds or blocks PD-L1. In certain embodiments, the disclosure relates to methods of using peptides or nanoparticles disclosed herein for the treatment of cancer. In certain embodiments, the disclosure relates to methods of using nanoparticles disclosed herein for therapeutic and diagnostic applications.