The present invention relates to plants having resistance to PPO inhibiting herbicides such as the herbicide oxyfluorfen conferred by a loss of function of one or more sulfolipid biosynthesis enzymes involved in the sulfolipid biosynthesis pathway and methods of producing said plants. The invention also relates to methods of producing a plant having resistance to PPO inhibiting herbicides, including but not limited to the herbicide oxyfluorfen, by modulating the expression of one or more sulfolipid biosynthesis genes and/or function of one or more sulfolipid biosynthesis enzymes involved in the sulfolipid biosynthesis pathway, and to plants produced by the methods.