Methods for biosynthesising hydrocarbons from a gaseous substrate in non-naturally occurring acetogens as well as non-naturally occurring acetogens for production of hydrocarbons are provided.

Disclosed herein are therapeutic agents capable of increasing the expression level of an epigenetic marker described herein. Also described herein are therapeutic agents that reduce or slow-down an aging phenotype.

Methods for biosynthesising hydrocarbons from a gaseous substrate in non-naturally occurring acetogens as well as non-naturally occurring acetogens for production of hydrocarbons are provided.

Disclosed herein are therapeutic agents capable of increasing the expression level of an epigenetic marker described herein. Also described herein are therapeutic agents that reduce or slow-down an aging phenotype.

Recombinant microbes comprising a novel pathway for producing fatty acid derivatives, such as fatty acid methyl esters, fatty acid ethyl esters, fatty alcohols, and fatty alcohol acetates, while generating low levels of 3-hydroxy fatty acid byproducts are provided herein. The addition of a heterologous R-3-hydroxy-acyl-CoA dehydratase or a heterologous R-specific enoyl-CoA hydratase and optionally a heterologous trans-2-enoyl-CoA reductase to a recombinant microbe reduces the amount of 3-hydroxy fatty acid byproducts produced by the acyl-ACP dependent fatty acid biosynthesis pathway of the recombinant microbe. Methods of producing the fatty acid derivatives are also provided, in addition to cell cultures and fatty acid derivative compositions produced by the recombinant microbes. The fatty acid derivatives produced by the recombinant microbes may be used to produce fragrances, pheromones, pharmaceutical agents, nutraceuticals or precursors thereof.