An object of the present disclosure is to provide a novel method for producing a fluorine-containing organic compound by electrolytic fluorination, and the like. The object can be achieved by a method for producing a fluorine-containing organic compound (1), comprising step A of subjecting an organic compound (2) to electrolytic fluorination in the presence of 0.2 M or more of a metal fluoride, and a fluoroalcohol.

An object of the present disclosure is to provide a novel method for producing a fluorine-containing organic compound by electrolytic fluorination, and the like. The object can be achieved by a method for producing a fluorine-containing organic compound (1), comprising step A of subjecting an organic compound (2) to electrolytic fluorination in the presence of 0.2 M or more of a metal fluoride, and a fluoroalcohol.

The present teachings relate to a methods for drug discovery. In one particular example, the method includes providing a substrate, modifying the substrate by using an electrochemical fluorination, screening a reaction mixture of the electrochemical fluorination, and identifying a fluorinated compound in the reaction mixture.

Provided herein are methods of fluorinating organic compounds. The electrochemical fluorination and radiofluorination of organic molecules using the cation pool technique is described, where the 18F and/or 19F-fluorine ions are added after the process of electrochemical oxidation, i.e., after formation of a carbocationic organic compound (i.e., a compound having a carbon atom with a positive charge).

Provided herein are methods of fluorinating organic compounds. The electrochemical fluorination and radiofluorination of organic molecules using the cation pool technique is described, where the 18F and/or 19F-fluorine ions are added after the process of electrochemical oxidation, i.e., after formation of a carbocationic organic compound (i.e., a compound having a carbon atom with a positive charge).

A process for the manufacture of nonafluoro-tert-butyl alcohol includes the use of a hydroxyl group protected nonafluoro-tert-butyl alcohol ester as an intermediate. The hydroxyl group protected nonafluoro-tert-butyl alcohol ester is obtained by subjecting a hydroxyl group protected tert-butyl alcohol ester compound to an electrofluorination (ECF) step. Deprotecting the hydroxyl group protected nonafluoro-tert-butyl alcohol ester results in the unprotected nonafluoro-tert-butyl alcohol. An electrochemical microreactor can be used in the ECF step for the manufacture of the nonafluoro-tert-butyl alcohol compound.

A process for the manufacture of nonafluoro-tert-butyl alcohol includes the use of a hydroxyl group protected nonafluoro-tert-butyl alcohol ester as an intermediate. The hydroxyl group protected nonafluoro-tert-butyl alcohol ester is obtained by subjecting a hydroxyl group protected tert-butyl alcohol ester compound to an electrofluorination (ECF) step. Deprotecting the hydroxyl group protected nonafluoro-tert-butyl alcohol ester results in the unprotected nonafluoro-tert-butyl alcohol. An electrochemical microreactor can be used in the ECF step for the manufacture of the nonafluoro-tert-butyl alcohol compound.