A material includes nonwoven fibers and a surface modification that crosslinks the nonwoven fibers together. The surface modification can include chemical reactive groups. The reactive groups can be selected from diisocyanates, alcohols, epoxides, imides, amides, imines, amines, diacrylates, disiloxanes and disilazanes. A method of forming the material electrospins fiber material in the form of fibers into a nonwoven material. A surface modification is introduced to the fibers either by modifying the fiber material before the electrospinning or by modifying the fiber surface after the electrospinning. The fibers are crosslinked to form the crosslinked nonwoven material.

An antiviral coating composition is provided. An antiviral coating composition according to one embodiment of the present invention is implemented by including an antiviral component comprising an antiviral fusion protein in which an antiviral motif is bound to an adhesive protein. According to the present invention, the composition has excellent processability enabling easy provision on various surfaces of various products, has adhesion sustainability enabling an adhesive state to be maintained for a long period of time after being adhered to a surface, and has activity sustainability enabling antiviral activity to be maintained for a long period of time without a loss in activity according to external conditions during preparation, storage and use.

An electrospinning device includes: a plurality of nozzles that discharge a spinning solution containing a resin; and a plurality of power sources for applying charge to the solution. The power sources are connected such that different charges are applied to the solutions discharged from the nozzles, respectively. The fiber sheet is a long fiber nonwoven fabric including first fibers and second fibers that are different from the first fibers. In a histogram based on fiber diameter distributions and frequencies of the numbers of fibers, the fiber sheet has a peak where a ratio P1 of a frequency of the number of fibers of the first fibers to a frequency of the number of fibers of the second fibers is 0.01 or more and 100 or less. Alternatively, the fiber sheet has two or more peaks in the histogram, in which a ratio P2 of a frequency of the number of fibers of the first fibers at a highest peak in a range of a fiber diameter of 3 μm or less to a frequency of the number of fibers of the second fibers at a highest peak in a range of a fiber diameter of more than 3 μm is 1 or more and 1 000 or less.

An electrospinning device includes: a plurality of nozzles that discharge a spinning solution containing a resin; and a plurality of power sources for applying charge to the solution. The power sources are connected such that different charges are applied to the solutions discharged from the nozzles, respectively. The fiber sheet is a long fiber nonwoven fabric including first fibers and second fibers that are different from the first fibers. In a histogram based on fiber diameter distributions and frequencies of the numbers of fibers, the fiber sheet has a peak where a ratio P1 of a frequency of the number of fibers of the first fibers to a frequency of the number of fibers of the second fibers is 0.01 or more and 100 or less. Alternatively, the fiber sheet has two or more peaks in the histogram, in which a ratio P2 of a frequency of the number of fibers of the first fibers at a highest peak in a range of a fiber diameter of 3 μm or less to a frequency of the number of fibers of the second fibers at a highest peak in a range of a fiber diameter of more than 3 μm is 1 or more and 1 000 or less.

Compositions-of-matter comprising a matrix made of one or more, preferably two or more elastic layers and one or more viscoelastic layer are disclosed. The compositions-of-matter are characterized by high water-impermeability and optionally by self-recovery. Processes of preparing the compositions-of-matter and uses thereof as tissue substitutes or for repairing damaged tissues are also disclosed.

A nanofibrous mat comprising: electrospun nanofibres forming said mat; and ceramic particles dispersed throughout said nanofibres and comprising a ceramic matrix and a dopant releasably encapsulated within said ceramic matrix, wherein the ceramic particles are dispersed throughout the nanofibres during electrospinning of the nanofibres, whereby said dopant is protected by said ceramic matrix during said electrospinning.

A nanofibrous mat comprising: electrospun nanofibres forming said mat; and ceramic particles dispersed throughout said nanofibres and comprising a ceramic matrix and a dopant releasably encapsulated within said ceramic matrix, wherein the ceramic particles are dispersed throughout the nanofibres during electrospinning of the nanofibres, whereby said dopant is protected by said ceramic matrix during said electrospinning.

A functionally gradient material for guided periodontal hard and soft tissue regeneration includes a 3D printed scaffold layer and an electrospun fibrous membrane layer. The content of hydroxyapatite in the 3D printed scaffold layer is higher than the content of hydroxyapatite in the electrospun fibrous membrane layer. The pore size of the 3D printed scaffold layer is larger than the pore size of the electrospun fibrous membrane layer. The pore size of the 3D printed scaffold layer is 100-1000 μm, and the fiber diameter of the electrospun fibrous membrane layer is 300-5000 nm. The electrospun fibrous membrane layer is in a random distribution or an oriented arrangement or has a mesh structure. The thickness of the electrospun fibrous membrane layer is 0.08-1 mm.

A functionally gradient material for guided periodontal hard and soft tissue regeneration includes a 3D printed scaffold layer and an electrospun fibrous membrane layer. The content of hydroxyapatite in the 3D printed scaffold layer is higher than the content of hydroxyapatite in the electrospun fibrous membrane layer. The pore size of the 3D printed scaffold layer is larger than the pore size of the electrospun fibrous membrane layer. The pore size of the 3D printed scaffold layer is 100-1000 μm, and the fiber diameter of the electrospun fibrous membrane layer is 300-5000 nm. The electrospun fibrous membrane layer is in a random distribution or an oriented arrangement or has a mesh structure. The thickness of the electrospun fibrous membrane layer is 0.08-1 mm.

The present invention relates to electrospun fibers comprising i) a hydrophilic polymer that is soluble in a first solvent, ii) a bioadhesive substance that is slightly soluble in said first solvent, iii) optionally, a drug substance.