The present invention refers to a process for the elaboration of a formulation based on polyurethane and mucilage of Opuntia ficus-indica with applications in the manufacturing of synthetic skin-like flexible coatings, in combination with textile substrates such as polyester, cotton, polyester and cotton10 or, with polymers such as PVC, polyurethane, among others, independently of whether it is water-based or oil-based, so that the warp of the substrate allows the generation of rolls of the coating for multiple uses and applications such as tapestry, book cover or as a substitute for coating covers for different objects that require a coating providing an external protection; this formulation has multiple applications since it has the advantage of being biodegradable and it lowers the use of contaminating plastics that contaminate the environment