An aspect provides a ventilation manifold for a ventilator, the manifold comprising a fluid flow path, the flow path comprising: bifurcated end paths, a constriction path and a compressed breathable gas chamber fluidly coupled to a compressed breathable gas source, the manifold having a manifold axis defined by the constriction path; a source path of the bifurcated ends coupled to an outlet conduit for a ventilator to present the compressed breathable gas at a source angle to one side of the manifold axis; and a vent path at a vent angle to the manifold axis for an exhaust flow, the vent path acting to provide a fluid pressure valve upon an inlet compressed breathable gas from the constriction path to urge flow towards the source path and a by-pass for returned outlet spent gas flow from the source path against the inlet compressed breathable gas at the constriction path, the fluid pressure valve and the by-pass dependent upon the relative magnitudes of the source angle and the vent angle to the manifold axis and/or each other along with the configuration of the constriction path and/or the configuration of the source path and/or the vent path.

Provided herein is a method for assisting breathing in a subject, the method including passing a pressurized airflow through a fluidic diverter, wherein the fluidic diverter converts the airflow into pulses of pressurized air that are diverted alternately to provide a first and a second train of pulses of pressurized air; and directing the first and second trains of pulses of pressurized air into a nasal passageway of a subject to assist breathing. Also provided herein is a device for assisting breathing, including an airflow source coupled to a fluidic diverter. The devices and methods provided herein generate positive airway pressure in the form of pulsatile vortex airflow for the treatment of obstructive sleep apnea in a subject, without the need for a sealed interface between the subject and the device.

The invention relates to a medical sensor system (10) for detecting a feature (12), such as an analyte, in a human or animal body. The system (10) includes at least one sensor (14; 34) having a reservoir (18) with a cap (16) designed as a controllable organic membrane (20), wherein (for example) application of a voltage of a particular magnitude, or application of a voltage for a particular time, effects a change in the permeability of the membrane (20).

The invention relates to a medical sensor system (10) for detecting a feature (12), such as an analyte, in a human or animal body. The system (10) includes at least one sensor (14; 34) having a reservoir (18) with a cap (16) designed as a controllable organic membrane (20), wherein (for example) application of a voltage of a particular magnitude, or application of a voltage for a particular time, effects a change in the permeability of the membrane (20).