A fluidic valve for a sample separation apparatus for separating a fluid, wherein the fluidic valve comprises a stack of connected layer structures, a first conduit within the stack, a second conduit within the stack, a movable body within the stack, and an actuator configured for actuating the movable body to selectively bring the movable body into a flow enabling configuration in which flow of fluid between the first conduit and the second conduit is enabled, or into a flow disabling configuration in which flow of fluid between the first conduit and the second conduit is disabled.

One aspect of the invention provides a multichamber bioreactor. The multichamber bioreactor includes multiple planar layers stacked on each other defining at least one chamber and a clamping mechanism. The clamping mechanism includes a housing and retaining means received in the housing and configured to generate a controlled and uniform pressure to secure the stacked multiple planar layers in the housing. Each chamber is implemented from a separate fluidic layer, with each fluidic layer having ports and valves independent of the other layers. The micro fluidic ports can be actuated through a micro fluidic interconnect system utilizing rotary cylinder valves.

In one example, a semiconductor device comprises a cavity substrate comprising a base and a sidewall to define a cavity, an electronic component on a top side of the base in the cavity, a lid over the cavity and over the sidewall, and a valve to provide access to the cavity, wherein the valve has a plug to provide a seal between a cavity environment and an exterior environment outside the cavity. Other examples and related methods are also disclosed herein.

A valve for switching of media, such as liquids or gases, is opened, closed or put into an intermediate state by at least one actuator produced from a shape memory alloy. The at least one actuator, as a function of whether electricity is applied to it, acts on at least one valve ball or a valve plunger accommodated in a core element, so that the through-flow of a medium through a fluid part below the core element, with a media-tight membrane interposed between, is opened, interrupted or partially opened in regulated or controlled manner. The core element is produced from a mechanically rigid and thermally well-conductive material, has electrical conductor tracks for electrical connection of the actuator to a supply of electricity on the top side, as well as multiple threaded through-holes for underside connection with the fluid part and the membrane and/or for top-side connection with the actuator.

A microvalve comprising a hard base 14, a clamping plate 12, an inlet port 96, 98, an outlet port 96, 98, a membrane 16, a ball bearing 18 and a drive head 20; wherein the hard base comprises a recess over which the membrane is clamped by the clamping plate, the recess defining a cup with a generally spherical cap shaped surface and a perimeter, both of the inlet and outlet ports being in the recess, and at least one of them being in the generally spherical cap shaped surface; wherein the membrane extends across the recess and is clamped thereover, and it is flexible for enabling the unclamped part of it to be flexed into the recess by the ball bearing in the clamping plate on the other side of the membrane to the recess upon actuation by the drive head behind the ball bearing for selective driving of the ball bearing against the membrane to flex the membrane into the recess as the membrane flexes around part of the ball bearing to move the membrane from a condition in which both ports are open to a port closing condition, the port closing condition being where the membrane has been flexed to extend over either one of, or alternatively both of, the input port and the output port, and clamped thereagainst by the ball bearing.

A valve for switching of media, such as liquids or gases, is opened, closed or put into an intermediate state by at least one actuator produced from a shape memory alloy. The at least one actuator, as a function of whether electricity is applied to it, acts on at least one valve ball or a valve plunger accommodated in a core element, so that the through-flow of a medium through a fluid part below the core element, with a media-tight membrane interposed between, is opened, interrupted or partially opened in regulated or controlled manner. The core element is produced from a mechanically rigid and thermally well-conductive material, has electrical conductor tracks for electrical connection of the actuator to a supply of electricity on the top side, as well as multiple threaded through-holes for underside connection with the fluid part and the membrane and/or for top-side connection with the actuator.

The present application discloses a micro-valve comprising: a first valve body and a second valve body, at least one of the first and second valve bodies defining a valve chamber and a valve seat, the first valve body having a liquid outlet and the second valve body having a liquid inlet; a valve plug disposed and movable within the valve chamber; and an elastic member disposed within the valve chamber and positioned closer to the liquid inlet than the valve plug. The elastic member has a liquid-inflow position and a liquid-outflow position, and in the liquid-inflow position, the elastic member enables liquid to flow from the liquid inlet through the elastic member to the liquid outlet, in the liquid-outflow position, the valve plug compresses the elastic member, such that the compressed elastic member seals the valve seat, or the compressed elastic member together with the valve plug seals the valve seat, so as to prevent liquid from flowing back from the liquid outlet to the liquid inlet through the valve seat.

Disclosed is a system including a flow control assembly. The system may include a flow regulating shunt system, for various purposes. The flow control assembly may be controlled according to selected parameters and methods.

A rotary planar peristaltic micropump (RPPM) includes an actuator having a shaft engaged with a motor such that activation of the motor causes the shaft to rotate, and a bearing assembly engaged with the shaft. The bearing assembly has a bearing cage defining a plurality of spaced-apart openings thereon, and a plurality of rolling-members accommodated in the plurality of spaced-apart openings of the bearing cage, such that when the shaft rotates, the plurality of rolling-members of the bearing assembly rolls along a circular path. The RPPM also includes a fluidic path in fluidic communication with first and second ports. The fluidic path is positioned under the actuator and coincident with the circular path, such that when the shaft of the actuator rotates, the plurality of rolling-members of the bearing assembly rolls along the fluidic path to cause a fluid to transfer between the first and second ports.

A fluidic valve for a sample separation apparatus for separating a fluid, wherein the fluidic valve comprises a stack of connected layer structures, a first conduit within the stack, a second conduit within the stack, a movable body within the stack, and an actuator configured for actuating the movable body to selectively bring the movable body into a flow enabling configuration in which flow of fluid between the first conduit and the second conduit is enabled, or into a flow disabling configuration in which flow of fluid between the first conduit and the second conduit is disabled.