The valve plate (1) with free micro-balls allows a fluid (2) to flow from an upstream volume (3) to a downstream volume (4) and not in the reverse direction, and comprises a circulation plate (5) crossed through by a circulation orifice (6) terminated by a micro-ball seat (7), a permeable guide plate (9) parallel to said plate (5) being crossed through by a guide cylindrical orifice (10) which houses a micro-ball (8) which rests on said seat (7) so as to close said orifice (6) or rests on a permeable micro-ball stop abutment (11), a spacer (12) being interposed between said plate (9) and said plate (5), a discharge passageway (13) crossing through said plate (9) to allow the fluid (2) to flow when the micro-ball (8) does not rest on said seat (7).

The invention relates to a substrate for testing samples, in particular cells or molecules, wherein the substrate comprises a fluid system comprising a sample chamber configured in the substrate for storing and testing samples and at least one liquid reservoir in fluid communication with the sample chamber, and wherein the substrate comprises a passive blocking element capable of assuming a closed position and an open position, wherein in the closed position a fluid exchange between the sample chamber and the liquid reservoir is blocked.

In one aspect of the invention, the fluidic device includes a fluidic chip includes a body having a first surface and an opposite, second surface, one or more channels formed in the body in fluidic communications with input ports and output ports for transferring one or more fluids between the input ports and the output ports, and a fluidic chip registration means formed on the first surface for aligning the fluidic chip with a support structure; and an actuator configured to engage with the one or more channels at the second surface of the body for selectively and individually transferring the one or more fluids through the one or more channels from at least one of the input ports to at least one of the output ports at desired flowrates.

Microscale valves for use in, e.g., micropump devices, may be formed of a slitted diaphragm bonded to the interior of a valve tube. A bump in the diaphragm and/or a backward-leakage stopper may increase the breakdown pressure of the valve. A push-rod may be used to pre-load the valve membrane to thereby increase the cracking pressure.

The microfluidic devices and systems disclosed herein reduce sample loss and help decrease sample processing bottlenecks for applications such as next generation sequencing (NGS). The microfluidic devices include a plurality of reaction modules. Each reaction module may comprise one or more reaction circuits. Each reaction circuit may comprise a single reaction flow channel with each reaction circuit connected by a bridge flow channel. Alternatively, each reaction circuit may comprise two or more reaction flow channels connected by two or more bridge flow channels. The combination of any two bridge flow channels and a portion of the two or more reaction flow channels between the any two bridge flow channels defining may define the reaction circuit. The reaction module may be arranged as nodes connected by bridge flow channels or each reaction module may be arranged in a parallel fashion on the microfluidic device.

A thin gas transportation device includes an inlet plate, a resonance sheet, an actuating element, a first insulation frame attached to the actuating element, a conductive frame, and a second insulation frame attached to the conductive frame. The conductive frame has a conductive outer frame attached to the first insulation frame, an elastic conductive pin, and a conductive piece connected to an outer edge portion of the conductive outer frame. One end of the elastic conductive pin is connected to an inner edge portion of the conductive outer frame, and the other end of the elastic conductive pin extends obliquely toward the actuating element and forms a bent portion. The bent portion presses against the actuating element and is electrically connected to the actuating element, and the bent portion is strip-shaped.

Pneumatic devices for implementing finite state machines are provided. In some implementations, the pneumatic device comprises a state register component configured to hold one of a set of possible states. The pneumatic device also comprises a next-state logic block component configured to determine a next state for the state register component based at least in part on a current state of the state register component. A pneumatic programmable logic array (PLA) implementing a next state logic block of a finite state machine is also provided. The pneumatic PLA comprises an elastomeric membrane containing a pattern of holes and disposed between two channel layers of a pneumatic device. The PLA receives one or more input values representing a current state of a state register and one or more input values representing a user input and calculates one or more output values representing a next state for the state register.

A microfluidic check valve includes an inlet bore, an internal chamber, an outlet bore, and a disk freely movable in the chamber between an open position and a closed position. At the open position, the disk permits fluid to flow from the inlet bore, through the chamber, and to the outlet bore. At the closed position, the disk prevents fluid from flowing in the reverse direction from the chamber into the inlet bore. The check valve may be positioned in-line with a fluid conduit, and/or incorporated with various fluidic devices such as, for example, capillary tubes, fittings, and chromatography columns. The check valve is capable of withstanding high fluid pressures, while featuring a small swept volume, such as a nano-scale volume. The check valve may be utilized, for example, to prevent fluid back flow and isolate pressure pulses in fluid flow systems.

A disc pump valve for controlling the flow of fluid through a disc pump includes a first plate having first plate apertures and a second plate having second plate apertures both extending generally perpendicular through the first plate and the second plate, respectively. The second plate apertures are substantially offset from the first plate apertures. The disc pump valve also includes a sidewall disposed between the first plate and second plate. A valve flap is disposed and moveable between the first plate and second plate. The valve flap includes flap apertures substantially offset from the first plate apertures and substantially aligned with the second plate apertures, and low-mass areas. The low-mass areas are offset from the first plate apertures and second plate apertures. The valve flap moves between the first plate and second plate in response to a change in direction of differential pressure of the fluid outside the valve.

A micro check valve includes a substrate body having a top side and an underside, at least the top side having a sealing bar between a first trough and a second trough. The substrate body also has a passage which leads from the underside of the substrate body to the top side of the substrate body and ends on the top side of the substrate body in the first trough. In addition arranged on the top side of the substrate body is a diaphragm which is mounted flexibly at least in the region of the sealing bar and the first and second troughs. The diaphragm also has at least one through opening arranged above the second trough.