This document describes fluid coupling devices for fluid systems and methods of using the fluid coupling devices. Some fluid coupling devices described herein are configured for use in fluid systems for the purpose of providing a sterile connection. Such a sterile connection can be useful for the delivery and/or processing of therapeutic agents, or ingredients thereof, and other purposes.

This document describes fluid coupling devices for fluid systems and methods of using the fluid coupling devices. Some fluid coupling devices described herein are configured for use in fluid systems for the purpose of providing a sterile connection. Such a sterile connection can be useful for the delivery and/or processing of therapeutic agents, or ingredients thereof, and other purposes.

A connector assembly includes a first and a second component. Each of the components including a connector body, a valve, a handle, a handle lock, and a connector lock. The handles open and close respective valves. Each of the handles has locked and unlocked positions. The handle locks prevent or inhibit the respective handles from being moved between open and closed positions. The handle locks in unlocked positions enable the respective handles to be moved between open and closed positions. The first and second components are configured to be releasably assembled with each other. The connector locks in their respective closed positions assist in preventing or inhibiting the disassembling of the first and second components.

A connector assembly includes a first and a second component. Each of the components including a connector body, a valve, a handle, a handle lock, and a connector lock. The handles open and close respective valves. Each of the handles has locked and unlocked positions. The handle locks prevent or inhibit the respective handles from being moved between open and closed positions. The handle locks in unlocked positions enable the respective handles to be moved between open and closed positions. The first and second components are configured to be releasably assembled with each other. The connector locks in their respective closed positions assist in preventing or inhibiting the disassembling of the first and second components.

An aseptic low-temperature coupling assembly includes a first connector, a second connector, and a gasket disposed in the first or the second connector. The first and second connectors include a first retaining feature and a second retaining feature configured to couple together the first and the second connectors and align openings in the first and second connectors. The gasket is formed to have no substantial deformation after being cooled to at least −50° C. then heated to ambient temperature. A method of aseptically connecting a low-temperature fluid storage container includes coupling a first connector to a second connector via first retaining features and second retaining features of the connectors. The coupling compresses a gasket between the first connector and the second connector and aligns an opening in the first connector with an opening in the second connector.

An aseptic low-temperature coupling assembly includes a first connector, a second connector, and a gasket disposed in the first or the second connector. The first and second connectors include a first retaining feature and a second retaining feature configured to couple together the first and the second connectors and align openings in the first and second connectors. The gasket is formed to have no substantial deformation after being cooled to at least −50° C. then heated to ambient temperature. A method of aseptically connecting a low-temperature fluid storage container includes coupling a first connector to a second connector via first retaining features and second retaining features of the connectors. The coupling compresses a gasket between the first connector and the second connector and aligns an opening in the first connector with an opening in the second connector.

The present invention relates to a hydraulic and/or pneumatic multi-coupler connector of the type comprising at least one pair of couplers inserted into a containment body and equipped with a lever actuated mechanism comprising an actuation lever maneuverable by the user for the relief of the residual pressure of the couplers and the connection thereof to corresponding male couplers.

Some fluid coupling devices described herein are configured for use in fluid systems for purposes of providing a single-use, disconnection functionality that can substantially limit fluid spillage when being disconnected. In some embodiments, the coupling portions cannot be functionally reconnected to each other after being disconnected from each other.

Some fluid coupling devices described herein are configured for use in fluid systems for purposes of providing a single-use, disconnection functionality that can substantially limit fluid spillage when being disconnected. In some embodiments, the coupling portions cannot be functionally reconnected to each other after being disconnected from each other.

Formation of a sterile connection includes inserting a first aseptic coupling device into a second aseptic coupling device while a locking ring of the first aseptic device is in an indexed initial position, rotating the locking ring to a secured position in which a compressive force is created and in which a first membrane from the first aseptic coupling device and a second membrane from the second aseptic coupling device can removed thereby resulting in a first a first sealing member of the first aseptic coupling device sealing with a second sealing member of the second aseptic coupling device to form a sterile fluid passageway.