A remote sampling sensor for determining characteristics of a sample includes measurement optics and an insertion probe. The measurement optics are configured to emit light and detect returned light. The insertion probe includes a chamber, the chamber being configured to permit the sample to enter the chamber, an insertion tip at a distal end of the insertion probe, and a retro-reflective optic adjacent the insertion tip. The retro-reflective optic is configured to return the light from the measurement optics through the chamber to the measurement optics. The insertion probe is configured to be remotely located from the measurement optics.

A Raman spectrometer 1 comprising a laser 1001 for illuminating a sample S under investigation, an auto-focusing system for focusing the laser 1001 on the sample S under investigation, and a detector 1010 for detecting Raman spectra emitted in response to illumination by the laser 1001. The auto-focusing system further comprises at least one adjustable focusing element for adjusting the location of the focus of the laser, a determination unit 1012 for determining a selected location for the focus of the laser 1001, and a control unit for adjusting the adjustable focusing element to focus the laser at said selected location determined by the determination unit 1012. The auto-focusing system is arranged under the control of software to enable determination of the selected location for the focus of the laser 1001.

Light detection systems are provided. Aspects of the light detection systems include first and second light receivers in fixed positions relative to each other, a plurality of wavelength separators configured to pass light from the first and second light receivers having a predetermined spectral range, and a plurality of light detection modules. Baseplates having a stage for mounting a light receiver, a plurality of recesses for fixing a plurality of light detection modules in rigid alignment relative to the stage, and a heat dissipation opening positioned within each recess are also provided. In addition, particle analysis systems, methods and kits for practicing the invention are disclosed.

Embodiments of the invention provide a method and system that allows parameters of a desired target image to be determined from hyperspectral imagery of scene. The parameters may be representative of various aspects of the scene being imaged, particularly representative of physical properties of the scene. For example, in some medical imaging contexts, the property being imaged may be blood perfusion or oxygenation saturation level information per pixel. In one embodiment the parameters are obtained by collecting lower temporal and spatial resolution hyperspectral imagery, and then building a virtual hypercube of the information having a higher spatial resolution using a spatiospectral aware demosaicking process, the virtual hypercube then being used for estimation of the desired parameters at the higher spatial resolution. Alternatively, in another embodiment, instead of building the virtual hypercube and then performing the estimation, a joint demosaicking and parameter estimation operation is performed to obtain the parameters. Various white level and spectral calibration operations may also be performed to improve the results obtained. While establishing functional and technical requirements of an intraoperative system for surgery, we present iHSI system embodiments that allows for real-time wide-field HSI and responsive surgical guidance in a highly constrained operating theatre. Two exemplar embodiments exploiting state-of-the-art industrial HSI cameras, respectively using linescan and snapshot imaging technology, were investigated by performing assessments against established design criteria and ex vivo tissue experiments. We further report the use of one real-time iHSI embodiment during an ethically-approved in-patient clinical feasibility case study as part of a spinal fusion surgery therefore successfully validating our assumptions that our invention can be seamlessly integrated into the operating theatre without interrupting the surgical workflow.

A mirror unit 2 includes a mirror device 20 including a base 21 and a movable mirror 22, an optical function member 13, and a fixed mirror 16 that is disposed on a side opposite to the mirror device 20 with respect to the optical function member 13. The mirror device 20 is provided with a light passage portion 24 that constitutes a first portion of an optical path between the beam splitter unit 3 and the fixed mirror 16. The optical function member 13 is provided with a light transmitting portion 14 that constitutes a second portion of the optical path between the beam splitter unit 3 and the fixed mirror 16. A second surface 21b of the base 21 and a third surface 13a of the optical function member 13 are joined to each other.

A Raman spectrometer arrangement comprising a Raman spectrometer 1 having a laser 1001 for illuminating a sample S and a spectrometer accessory 4 configured to be mounted on the spectrometer, wherein the spectrometer accessory comprises a surface configured to receive the sample S. The Raman spectrometer arrangement is configured to operate in at least a first configuration and a second configuration, wherein the first configuration is such that the laser 1001 illuminates the sample S before reaching a level of the surface and the second configuration is such that the laser 1001 reaches the level of the surface before illuminating the sample S.

A spectroscopic camera includes: a spectral filter having an optical area that transmits light with a predetermined wavelength from incident light; an image sensor receiving transmitted light transmitted through the spectral filter; and a casing accommodating the spectral filter and the image sensor. A direction in which the incident light enters is a first direction. The casing includes: a cylindrical lens mount which a lens that the incident light enters is attachable to and removable from and which has a center axis along the first direction; a wall having an aperture that has an aperture center coaxial with the center axis of the lens mount and that is smaller than a cylindrical inner diameter of the lens mount and equal to or smaller than an outer diameter of the optical area; a filter accommodation unit accommodating the spectral filter at such a position that the optical area covers the aperture, as viewed in a plan view along the first direction; and an imaging sensor accommodation unit provided downstream of the filter accommodation unit in the first direction and accommodating the image sensor at such a position that the image sensor overlaps the aperture as viewed in the plan view.

In an optical device, a base and a movable unit are constituted by a semiconductor substrate including a first semiconductor layer, an insulating layer, and a second semiconductor layer in this order from one side in a predetermined direction. The base is constituted by the first semiconductor layer, the insulating layer, and the second semiconductor layer. The movable unit includes an arrangement portion that is constituted by the second semiconductor layer. The optical function unit is disposed on a surface of the arrangement portion on the one side. The first semiconductor layer that constitutes the base is thicker than the second semiconductor layer that constitutes the base. A surface of the base on the one side is located more to the one side than the optical function unit.

Techniques are disclosed for a chemical sensor architecture based on a fabric-based spectrometer. An example apparatus implementing the techniques includes a portable spectrometer device including a first fabric layer and a second fabric layer coupled to the first fabric layer to form a pouch. The second fabric layer includes a fiber fabric spectrometer substrate comprising a fiber material including one or more electronic devices, wherein the pouch is configured to receive a colorimetric substrate and the fiber fabric spectrometer substrate is configured to measure reflectance of a colorimetric substrate disposed in the pouch.

An optical module includes a micro spectrometer. The micro spectrometer includes an optical crystal, a lens, and a photosensitive assembly. The optical crystal is configured to receive detection light and covert the detection light into interference light. The optical crystal is surrounded by a sleeve, the sleeve configured to fix a position of the optical crystal. The lens is configured for receiving the interference light and focusing the interference light. The photosensitive assembly is configured for imaging the interference light into an interference image. The optical module further comprises a controller. The controller is electrically connected to the photosensitive assembly, and the controller is used to convert the interference image into light wavelength signals and light intensity signals.