The present disclosure provides a sample rotation system and method. The sample rotation system includes a rotation device, and the rotation device includes: a first carrier connected to a sample; a drive portion connected to the first carrier, wherein the drive portion is configured to drive the first carrier to rotate; and the first carrier drives the sample to rotate from an initial position to a target position; an acquisition device, configured to acquire a rotation state of the sample; and a control unit, electrically connected to the drive portion, and configured to control operation of the drive portion.

In a method and device for assessing the quality of a processing operation, a workpiece with specific processing parameters is processed along a processing trajectory. The (X), wherein the processing result is measured by at least one sensor and at least one sensor signal is recorded and at least one quality parameter is determined based on at least one sensor signal and the at least one quality parameter is compared with quality parameter threshold values to assess the quality of the processing result. During the assessment of the processing operation quality, changes made to the processing parameters from target values during the processing are automatically taken into consideration, in that, instead of the quality parameter threshold values, quality parameter threshold values adapted to the changes in the processing parameters are determined, and the at least one quality parameter for assessing the quality of the processing result is compared with the adapted quality parameter threshold values.

Systems, apparatuses, and methods enable rapid, repeatable, and accurate dissection of arthropods. Arthropod dissection apparatuses includes a shear dissection mechanism having a primary shear body and a secondary shear body. The primary shear body includes at least an inlet channel, a first outlet channel, and a second outlet channel formed therein. The secondary shear body is disposed in an aperture of the primary shear body and has a dissection chamber formed therein. The secondary shear body is movable between a first position and a second position relative to the primary shear body, which causes a shearing action at a shearing interface between the secondary shear body and the primary shear body.

Methods of introducing a small molecule into a crystal of a macromolecule, of obtaining a microcrystal having a macromolecule and a small molecule from a crystal of the macromolecule, of determining a structural model for a complex having a macromolecule and a small molecule, of identifying a small molecule that complexes with a macromolecule, and of screening a library of small molecules for their binding to a macromolecule are disclosed.

A toilet is disclosed. The toilet has a bowl adapted to receive excreta, a shelf for receiving feces in the bowl, and one or more sensor for detecting a property of the feces. The property may be related to a user's heath and wellness and may be presented to a person for their review and assessment.

A high-throughput method of analyzing multiple tissue samples for nucleic acid material is presented. The method includes providing FFPE blocks containing tissue samples, a heatmap of locations of interest for each sample-containing FFPE block, and a coring device with a hollow punch tip. The sample-containing FFPE block is punched with the hollow punch tip at a location determined by the heatmap in order to obtain a core sample which is subsequently ejected out of the hollow punch tip to a designated receptacle. The hollow punch tip is sterilized after ejecting the core sample. These steps are repeated as needed to obtain desired number and typed core samples from the sample-containing FFPE blocks. The individual core samples are then treated in the individual designated receptacles with an appropriate reagent to extract nucleic acid material which is subsequently isolated and analyzed.

A seed sampling system is provided comprising an automated seed loading assembly operable to singulate seeds from a plurality of seeds or enable loading of individually stored seeds and an automated seed sampling assembly comprising at least one sampling module operable to remove tissue samples from one of the singulated seeds. The system also includes an automated seed transport assembly comprising at least one retention member operable to transfer the singulated seeds from at least one elevator unit of the seed loading assembly to the at least one sampling module of the seed sampling assembly. In connection therewith, the at least one sampling module includes multiple sampling locations, each associated with a sampler, where the at least one sampling module is operable to remove tissue samples from seeds at one of sampling locations while another one of the sampling locations is cleaned to remove residual seed tissue therefrom.

A Through-Silicon Via (TSV) product, a TSV sample, and a method for manufacturing the same are provided. The method includes operations as follows. A first metal layer is deposited on a bottom of each of TSVs, the first metal layer covering the bottom of the TSV. Pre-prepared adhesive is filled on an inner wall in a middle of each of TSVs of a to-be-processed sample. A second metal layer is deposited on a top of each of the TSVs, the second metal layer covering on the top of an opening of the TSV. A capping layer is deposited on the second metal layer, to obtain a preprocessed to-be-processed sample. The preprocessed to-be-processed sample is cut in a preset cutting manner by using a dual-beam Plasma Focused Ion Beam (PFIB), to form a TSV sample with a cross-section of each of the TSVs is exposed.

The subject matter disclosed herein is generally directed to isolating single cells and nuclei from tissue samples for use in the analysis of single cells from archived biological samples. The subject matter disclosed herein is directed to isolating single cells and nuclei from formalin-fixed paraffin-embedded (FFPE) tissues. The subject matter disclosed herein is also directed to isolating single nuclei that preserve ribosomes or ribosomes and rough ER from frozen tissues. The subject matter disclosed herein is also directed to therapeutic targets, diagnostic targets and methods of screening for modulating agents.

The invention relates to a device and the operating method therefor, for the fragmentation of a biological material within in a sealed sterile environment with an aseptic procedure.