Provided herein are methods of preserving a biological sample on a first substrate, the methods including: (a) disposing a biological sample on a first substrate; (b) delivering a spacer agent to the first substrate, wherein the spacer agent is applied around the biological sample on the first substrate, thereby generating a chamber around the biological sample; (c) delivering a mounting agent to the chamber; and (d) assembling the first substrate with a second substrate, thereby preserving the biological sample on the first substrate.

Disclosed is plate or film for collecting and analyzing a sample. The plate or film includes a surface and a plurality of slices from the sample immobilized on the surface. Further, the plurality of slices are cut from the sample with equal thickness, and the plurality of slices are placed on the surface of the plate or film following their cutting order.

A device for sand sampling through a water method includes a sampling cylinder and a triaxial sampler, where the sampling cylinder includes a cylinder, two ends of the cylinder being hermetically provided with an upper sealing cover and a lower sealing cover separately, one ends, facing inside of the cylinder, of the upper sealing cover and the lower sealing cover being provided with water-permeable stones, one end, facing outside of the cylinder, of the upper sealing cover being connected to a control valve, and the control valve being in communication with the inside of the cylinder; and the sampling cylinder is arranged in the triaxial sampler when sand sampling is performed through a water method, a lower end of the triaxial sampler is provided with a test operation table, and an upper end of the triaxial sampler is nested inside a restraint ring.

A system and method for automated transfer of a tape segment onto the face of a tissue block to be thin sectioned by microtomy includes applying, to a carrier strip, a plurality of serially-spaced patches of sample tape having an adhesive outer surface, transporting the carrier strip along a path adjacent to and spaced from the exposed sample surface to position one of the patches of sample tape adjacent to and covering the exposed sample surface, adhering the one of the patches of sample tape to the exposed sample surface.

Provided are: a biological tissue thin slice sample for imaging which is prepared for a mass spectrometer which can eliminate physical and chemical influences and can adhesively support a thin frozen slice of a hard tissue or a large biological tissue even at low temperatures; and a method for producing the sample. The present invention relates to a biological tissue thin slice sample having a biological tissue adhering to a conductive adhesive film. The electrical resistance value between two points spaced apart by 75 mm or more on the surface of the conductive adhesive film to which the biological tissue adheres is 1.0×10.sup.−2Ω or more and less than 2.0×10.sup.7Ω, and the median value of a glass transition temperature range of an adhesive of the conductive adhesive film determined by DSC measurement is −150° C. to −40° C. The present invention also relates to a method for producing the sample.

A special vertical embedding box for tomographic plastination comprises two panels oppositely provided and a sealing part provided in the two panels. The two panels are fixed by fixing pieces, and the sealing part comprises vertical sealing strips and a horizontal sealing strip that are connected between the two panels in a fixed manner. The horizontal sealing strip is provided between the lower portions of the two vertical sealing strips, thus forming a flat vertical space with an open upper end and the other three sides sealed. The embedding box is placed vertically during use, so that liquid medicine will not be spilled out. Acetone will escape from the top of the embedding box in the form of air bubbles during an infiltration process, so that there is no need to add polymers twice before curing, thus reducing process steps and drug consumption.

A tape for collecting tissue samples in a manner compatible with imaging in a transmission electron microscopy (TEM) system, includes a tape substrate having two side walls forming a trough. The trough is defined by a bottom surface of the tape substrate and internal surfaces of the side walls, with an open side therebetween. A support film is attached to a top surface of the tape substrate, and a plurality of apertures is spaced at predetermined locations along the length of the tape substrate, each aperture being covered by the support film. The tape includes a stacked configuration in which the tape substrate is wound in layers, the bottom surfaces of the side walls in one layer being in contact with the support film in an immediately adjacent layer. The apertures in the second layer are aligned within the trough of the first layer, between the side walls.

A spheroid tissue microarray comprises an array of tissue spheroids embedded within a porous mold. The product may be impregnated with a wax or resin and sectioned, and contains spheroids which are precisely located in a regular geometric grid. A method of manufacturing a spheroid tissue microarray comprises the steps of: forming a mold of porous material from liquid mold material in a casting mold, and allowing the liquid mold material to set; removing the porous mold from the casting mold; topping up the porous mold with further liquid mold material, and allowing recesses to form in the surface of the mold by the drawing-in of liquid mold material through shrinkage as the liquid mold material sets; placing tissue spheroids into the recesses in the surface of the porous mold; and sealing the tissue spheroids within the mold by topping off with liquid mold material and allowing the liquid mold material to set. An alternative method comprises the steps of: forming a mold of porous material from liquid mold material in a casting mold; allowing the liquid mold material to set; removing the porous mold from the casting mold; placing spheroids in recesses at the bases of wells in the mold of porous material; and sealing the spheroids within the porous mold by adding further porous material on top of the spheroids; wherein the recesses at the bases of the wells in the porous material are formed by protrusions of the casting mold carrying further, nipple-shaped, protrusions.

An automated tissue section slicing, staining, and imaging system efficiently registers full-resolution tissue section images by applying scaled transformation matrices computed to register downsampled tissue section images to the full-resolution tissue section images.

A system and method for automated transfer of a tape segment onto the face of a tissue block to be thin sectioned by microtomy includes applying, to a carrier strip, a plurality of serially-spaced patches of sample tape having an adhesive outer surface, transporting the carrier strip along a path adjacent to and spaced from the exposed sample surface to position one of the patches of sample tape adjacent to and covering the exposed sample surface, adhering the one of the patches of sample tape to the exposed sample surface.