The present disclosure describes a computer implemented method, a system, and a computer program product of calculating molar mass values of components of and molar concentration values of conjugate molecules/particles.

Device and method for detecting dispersed extracellular vesicles in a liquid dispersion sample, said method using an electronic data processor for classifying the sample as having, or not having, extracellular vesicles present, the method comprising the use of the electronic data processor for pre-training a machine learning classifier with a plurality of extracellular vesicle liquid dispersion specimens comprising the steps of: emitting a laser modulated by a modulation frequency onto each specimen; capturing a temporal signal from laser light backscattered by each specimen for a plurality of temporal periods of a predetermined duration for each specimen; calculating specimen DCT or Wavelet transform coefficients from the captured signal for each of the temporal periods; using the calculated coefficients to pre-train the machine learning classifier; wherein the method further comprises the steps of: using a laser emitter having a focusing optical system coupled to the emitter to emit a laser modulated by a modulation frequency onto the sample; using a light receiver to capture a signal from laser light backscattered by the sample for a plurality of temporal periods of a predetermined duration; calculating sample DCT or Wavelet transform coefficients from the captured signal for each of the temporal periods; using the pre-trained machine learning classifier to classify the calculated sample coefficients as having, or not having, extracellular vesicles present.

A closed system is provided for enlarging viral and bacterial particles for identification by diffraction scanning. The closed system includes a transparent tube, a deformable dispenser, a quantity of first antibodies, a quantity of second antibodies, and a diffraction scanning device. The transparent tube contains the quantity of first antibodies, the quantity of second antibodies, and receives the exhaled air from an individual. The deformable dispenser drives the quantity of second antibodies to mix with a complex formed by target matter in the exhaled air and the quantity of first antibodies. The quantity of first antibodies interacts with the target matter. The quantity of second antibodies interacts with the complex formed by the target matter and the quantity of first antibodies. The diffraction scanning device measures the number and size of particles within the transparent tube.

By irradiating target liquid L containing fine bubbles with ultrasonic waves from an ultrasonic irradiation device 102, the fine bubbles in the target liquid L is reduced. By irradiating the target liquid L with ultrasonic waves, fine bubbles in the target liquid L can be reduced effectively. By using ultrasonic waves, bubbles with small diameters, particularly fine bubbles, can be effectively reduced, so that fine bubbles in the target liquid L can be efficiently reduced.

Optical tweezer methods and apparatus that operate in reflection mode use polarization selection to isolate an input laser signal from optical signals associated with trapping. A trapping aperture or apertures can be defined in a conductive film such as a gold film have a polarization-dependent reflectance due to asymmetry of the aperture, and a reflected beam is polarized differently than an incident beam. Polarization of scattered light from the aperture can thus be distinguished from polarization of the incident beam. In some cases, an aperture is not used but instead polarizing nanoparticles, such as nanorods, are detected based on either transmitted or reflected optical radiation in a different state of polarization than that of the incident beam.

By irradiating target liquid L containing fine bubbles with ultrasonic waves from an ultrasonic irradiation device 102, the fine bubbles in the target liquid L is reduced. By irradiating the target liquid L with ultrasonic waves, fine bubbles in the target liquid L can be reduced effectively. By using ultrasonic waves, bubbles with small diameters, particularly fine bubbles, can be effectively reduced, so that fine bubbles in the target liquid L can be efficiently reduced.

The present disclosure describes a computer implemented method, a system, and a computer program product of calculating molar mass values of components of and molar concentration values of conjugate molecules/particles.

An ultrasonic particle size measurement device includes: a transducer for (i) receiving an ultrasonic pulse scattered after being emitted to a fine particle and (ii) generating a first scattering amplitude ; and a particle size calculating section for calculating a particle size of the fine particle by calculating an amplitude r and a phase in accordance with a real part and an imaginary part, respectively, of a second scattering amplitude obtained by subjecting the first scattering amplitude to a Fourier transform.

This invention enables high throughput detection of small molecule effectors of particle association, as well as quantification of association constants, stoichiometry, and conformation. Given a set of particle solutions having different concentrations, dynamic light scattering measurements are used to determine the average hydrodynamic radius, as a function of concentration. The series of average hydrodynamic radii as a function of concentration are fitted with stoichiometric association models containing the parameters of molar mass, modeled concentrations, and modeled hydrodynamic radii of the associated complexes. In addition to the average hydrodynamic radii value analysis, the experimental data may be fit/analyzed in alternate ways. This method may be applied to a single species that is self-associating or to multiple species that are hetero-associating. This method may also be used to characterize and quantify the association between a modulator and the associating species.

A particle beam forming device for forming either a linear or conical particle beam from a particle source in which particles are dispersed in a gas, includes: a reduced-pressure vessel in which pressure is reduced; a particle beam generating unit, which has one end arranged outside of the reduced-pressure vessel and an other end arranged inside the reduced-pressure vessel, and which captures the particle source from outside the reduced-pressure vessel and introduces the particle beam into the reduced-pressure vessel; and a particle beam evaluating unit for evaluating a spatial distribution of the particle beam inside the reduced-pressure vessel.