A method for monitoring a property of nanoparticles in a flowing suspension comprises providing a sample comprising a flowing suspension. The method further comprises non-invasively monitoring a size distribution of nanoparticles of the flowing suspension using Fourier domain low-coherence interferometry, FDLCI, wherein the monitoring comprises deriving a time and optical path length resolved LCI light scattering signal l(t,z) from time resolved LCI wavelength spectra of interference and deriving information indicative of the size of the particles in the sample based on said time and optical path length resolved LCI light scattering signal using optical path length resolved temporal autocorrelation functions or optical path length resolved frequency power spectra of the spatiotemporal FDLCI signal.

Devices, systems, and methods are disclosed for improved laser speckle imaging of samples, such as vascularized tissue, for the determination of the rate of movement of light scattering particles within the sample. The system includes a structure adjoining a light source and a photo-sensitive detector. The structure can be positioned adjacent the sample (e.g., coupled to the sample) and configured to orient the light source and detector relative the sample such that surface reflections, including specular reflections and diffuse reflections, are discouraged from entering the detection field of the detector. The separation distance along the structure between the light source and the detector may further enable selective depth penetration into the sample and biased sampling of multiply scattered photons. The system includes an operably coupled processor programmed to derive contrast metrics from the detector and to relate the contrast metrics to a rate of movement of the light scattering particles.

The present disclosure describes an apparatus and method of improving temperature uniformity and suppressing well plate warping. In an embodiment, the apparatus includes a barrier configured to be positioned above at least one well configured to contain a liquid sample, where a vessel includes the at least one well, where the vessel is transparent and is configured to be placed within a measurement chamber, where a light measurement apparatus includes the measurement chamber, where the light measurement apparatus is configured to measure light scattered from the liquid sample, where the barrier is configured to seal the at least one well from the measurement chamber, and a weighted lid configured to press a bottom surface of the vessel against a well plate retainer of the measurement chamber, thereby spreading heat among the at least one well and preventing the vessel from warping.

The present disclosure describes a method and apparatus of measuring dynamic light scattering of a sample. In an embodiment, the apparatus includes a platen, a light source underneath the platen and configured to emit emitted light through the platen and into the sample, collector optics underneath the platen and configured to capture scattered light, and an optical absorber configured to be in contact with the sample, configured to absorb transmitted light, and configured to redirect reflected light away from the collector optics. In an embodiment, the method includes depositing a sample on a platen, emitting emitted light from a light source underneath the platen through the platen and into the sample, capturing via collector optics underneath the platen scattered light, contacting the sample with an optical absorber, absorbing via the absorber transmitted light, and redirecting via the absorber reflected light away from the collector optics.

The present disclosure relates to a field programmable gate array (FPGA)-based multi-channel dynamic light scattering (DLS) autocorrelation system and method. The system includes a DLS generation apparatus, a photon correlator, and a host computer, where the photon correlator includes an FPGA and a universal serial bus (USB) communication module; the DLS generation apparatus is connected to the FPGA; the FPGA is configured to count and perform correlation calculation on photon pulses generated by the DLS generation apparatus; the USB communication module is connected to the host computer; the FPGA includes a dual counter module and a correlation calculation module; the dual counter module is connected to the DLS generation apparatus and the correlation calculation module; the correlation calculation module is connected to the USB communication module; the dual counter module includes a plurality of dual counters; and the correlation calculation module includes a plurality of correlators.

Disclosed herein is a system for performing urinalysis of transurethral patients. The system includes a tubing set to receive urine from a urethral catheter. A detector assembly is operatively coupled between the tubing set and a urinalysis module coupled. The system can perform urinalysis of a urine sample disposed within the tubing set and render urinalysis information on a display of the module. Also disclosed is a method of performing urinalysis that can include operations of: (i) placing a urine sample within a cuvette of a urinalysis system, the cuvette including a lumen extending between an inlet and an outlet; (ii) projecting coherent light into the sample; (iii) collecting output light exiting the sample; (iv)extracting urinalysis data from the collected light; and (v) rendering urinalysis results on a display of the system.

The present disclosure relates generally to the field of analyzing a nucleic acid, such as RNA, in particular to the determination of at least one parameter of a sample composition comprising a nucleic acid, especially RNA, and optionally particles.

An optical particle detector is configured to simultaneously detect at least two particles within a useful detection volume. The detector includes a retina capable of receiving light rays scattered by the particles and a dark reticle interposed between the useful detection volume and the retina. The dark reticle includes at least one optical aperture allowing a passage towards the retina of a part of first scattered light rays and of a part of second scattered light rays, and an opaque surface on a periphery of the at least one aperture, preventing a passage towards the retina of another part of the first and second scattered light rays so as to project onto the retina first and second scattering diagrams separated from each other.

The present invention relates to a method for measuring characteristics of particles in solution and to a device for performing the same, wherein said method comprises the steps of providing a vessel comprising a sample of said particles in solution, wherein the sample has preferably a volume between 0.1 μL and 15 μL, providing a monochromatic light source and a light detector, transmitting light from the monochromatic light source to the vessel comprising the sample, detecting light emitted from the vessel with the light detector, and determining characteristics of said particles in solution comprised in the sample based on a dynamic light scattering (DLS) measurement.

An apparatus includes a process chip and a dynamic light scattering assembly. The process chip includes a fluid chamber including and an optically transmissive material adjacent to the fluid chamber. The process chip is to be removably positioned in relation to the dynamic light scattering assembly. The dynamic light scattering assembly is to direct the light through the optically transmissive material and into the fluid chamber. The dynamic light scattering assembly is further to receive light scattered by particles in fluid in the fluid chamber in response to the first optical fiber emitting light into the fluid chamber and thereby capture light scattering data. A processor determines viscosity of fluid in the fluid chamber based on the captured light scattering data. The processor also determines one or both of size or size distribution of particles in the fluid based the captured light scattering data.