A cartridge and system involving a joint spectroscopic and biosensor blood analyzer for measurement of at least two hemoglobin species in a patient's blood sample by spectroscopy, and measurement of at least pH of the blood sample by biosensor, for assessing the patient's oxygenation and acid-base status. The cartridge comprises a housing having a first housing member and a second housing member bonded together by a gasket. The housing comprises a cartridge inlet; a blood storage conduit; an optical chamber; a biosensor conduit; a waste receptacle; a vent; an air bladder, an air bladder exit port; and, an optical window and an aligned optical member, the aligned optical member being one of a reflecting member or a second optical window, and being positioned to align with at least a portion of the optical chamber and at least a portion of the optical window.

The invention relates to a counting chamber for a microscope, adjustable in height. The method measures a cell count at two different chamber heights and deduces the concentration of particles without an exact calibration of the absolute height, as the height difference gives a measurement of the missing volume and therefore an estimate of the particle concentration.

A portable device for detecting an analyte associated with a target organic molecule in a liquid and/or solid substance. The device includes a test chamber, a probe, and a sensor. The test chamber contains a liquid volume of test solution including an analytical reagent selected to react with the analyte. The test chamber is sealed by a pierceable membrane wall. The probe is removably positionable to pierce the membrane wall to deposit a sample in the test chamber to form a test mixture with the test solution. The sensor is positioned to detect one or more characteristics of the test mixture in the test chamber indicative of a reaction between the analyte and the analytical reagent.

A light-emitting module for use in a system for measuring whole-blood hemoglobin parameters or whole-blood bilirubin parameters. The light-emitting module includes an LED light source capable of emitting light wherein the light is directed thereby defining an optical path and a plurality of optical components. The plurality of optical components includes a collimating lens, a first optical diffuser, a circular polarizer, and a focusing lens wherein the plurality of optical components is disposed within the optical path of the light from the LED light source.

The present invention relates to a hand-held microfluidic detection device, comprising: a microfluidic cell (M) having at least one chamber intended to at least contain a sample; a support (S) comprising a housing for the removable attachment thereto of the microfluidic cell (M); excitation light means arranged at least in part in the support (S) to side illuminate the at least one chamber of the microfluidic cell (M) to excite the sample contained therein; an optical detector (D) configured and arranged to detect light emitted from the sample when excited with said side illumination; and a casing (C) constituting an envelope into which at least the support (S) is housed and attached.

A portable device for detecting an analyte associated with a target organic molecule in a liquid and/or solid substance. The device includes a test chamber, a probe, and a sensor. The test chamber contains a liquid volume of test solution including an analytical reagent selected to react with the analyte. The test chamber is sealed by a pierceable membrane wall. The probe is removably positionable to pierce the membrane wall to deposit a sample in the test chamber to form a test mixture with the test solution. The sensor is positioned to detect one or more characteristics of the test mixture in the test chamber indicative of a reaction between the analyte and the analytical reagent.

Embodiments as disclosed herein may provide a sensor system including a container, such as a bag, having a port assembly integrated therewith. The port assembly includes an optically transparent window and be configured such that a sensor may be mechanically attached to the port assembly to interface with the optical window. The sensor may include an index of refraction (IoR) sensor that measures the chemical concentration of a liquid inside the container based on a refractive index.

Apparatus and methods are described for determining a property of a bodily sample using a microscope and optical-density-measurement apparatus, the apparatus including a sample carrier that includes a plurality of microscopy sample chambers configured to receive a first portion of the sample and to facilitate imaging of the first portion of the sample by the microscope, each of the microscopy sample chambers having an upper and a lower surface, and having respective heights between the upper and lower surfaces that are different from each other. The sample carrier includes at least one optical-density-measurement chamber configured to receive a second portion of the sample, and to facilitate optical density measurements being performed optical-density-measurement apparatus upon the second portion of the sample. Other applications are also described.

An optical component group for use in a spectrometer module of a system for measuring whole-blood hemoglobin parameters or whole-blood bilirubin parameters. The optical component group includes a light dispersing element and an achromatic lens assembly disposed between the light dispersing element and a light entrance port of the spectrometer module where the achromatic lens assembly is thermo-compensating permitting thermal expansion and contraction of the achromatic lens assembly in a linear direction where the linear directions is also transverse to a light beam from the light entrance port through the achromatic lens assembly and to the light dispersing element and back through the achromatic lens assembly.

A replaceable cuvette assembly for use in an optical absorbance measurement system for measuring whole-blood hemoglobin parameters or whole-blood bilirubin parameters. The replaceable cuvette assembly includes a cuvette substrate and a cuvette module fixedly connected to the cuvette substrate wherein the cuvette substrate is a support for securing the cuvette assembly within the optical absorbance measurement system. The cuvette module has a sample inlet port, a sample outlet port, an electronic chip assembly, a sample receiving chamber that fluidly communicates with the sample inlet port and the sample outlet port, a first cuvette window, and a second cuvette window forming a portion of the sample receiving chamber. The first cuvette window and the second cuvette window are aligned with each other defining a cuvette optical path length between the first cuvette window and the second cuvette window and disposed within an optical path of the optical absorbance measurement system.