G01N2021/0321

Sample carrier for microscopy and optical density measurements

Apparatus and methods are described for determining a property of a bodily sample using a microscope and optical-density-measurement apparatus, the apparatus including a sample carrier that includes a plurality of microscopy sample chambers configured to receive a first portion of the sample and to facilitate imaging of the first portion of the sample by the microscope, each of the microscopy sample chambers having an upper and a lower surface, and having respective heights between the upper and lower surfaces that are different from each other. The sample carrier includes at least one optical-density-measurement chamber configured to receive a second portion of the sample, and to facilitate optical density measurements being performed optical-density-measurement apparatus upon the second portion of the sample. Other applications are also described.

DISPLACEABLE RECEPTACLE FOR TEST SAMPLE
20220326154 · 2022-10-13 · ·

A system for containing a sample for analysis by a spectrometer, comprising a sample receptacle unit with a well for containment of the sample, the well comprising a well inner wall and well floor, a floor aperture in the well floor, and comprising a first spectroscopy element, the first spectroscopy element spanning the opening of floor aperture, wherein the well further comprises a sealing material at the interface of the inner wall with the first spectroscopy element, wherein radiation is free to pass through the floor aperture to the first spectroscopy element.

Analyte system and method for determining hemoglobin parameters in whole blood
20170227521 · 2017-08-10 ·

A system of measuring hemoglobin and bilirubin parameters in a whole blood sample using optical absorbance. The system includes an optical-sample module, a spectrometer module, an optical fiber module optically connecting the optical-sample module to the spectrometer module, and a processor module. The optical-sample module has a light-emitting module having a LED light source, a cuvette and a calibrating-light module. The processor module receives and processes an electrical signal from the spectrometer module and transforms the electrical signal into an output signal useable for displaying and reporting hemoglobin parameter values and/or total bilirubin parameter values for the whole blood sample.

Sample carrier for microscopy measurements

Apparatus and methods for determining a property of a bodily sample using a microscope are described. A sample carrier includes a plurality of microscopy sample chambers configured to receive a least a portion of the bodily sample, while the sample is imaged by the microscope. Each of the microscopy sample chambers has an upper and a lower surface, and the microscopy sample chambers have respective heights between the upper and lower surfaces that are different from each other. The sample carrier defines a microscopy sample chamber inlet hole, that is fluid communication with all of the microscopy sample chambers, such as to facilitate filling of all of the microscopy sample chambers with the portion of the bodily sample, via the microscopy sample chamber inlet hole. Other applications are also described.

Method to Detect Diesel in Fluid Samples
20230384210 · 2023-11-30 ·

A method includes providing a cuvette containing a fluid sample having a first substance and emitting light from a light source through the cuvette containing the fluid sample for a duration of time. The cuvette is made of a material that at least partially dissolves in the presence of the first substance. Over the duration of time, the cuvette at least partially dissolves and an intensity of light that passes through the cuvette and the fluid sample changes at a rate. The method also includes receiving, by a light detector, the light that passed through the cuvette, measuring a change in intensity of the received light over the duration of time, and determining that the rate of change in intensity of the light over the duration of time is greater than a threshold rate of change.

Portable organic molecular sensing device and related systems and methods

A portable device for detecting an analyte associated with a target organic molecule in a liquid and/or solid substance. The device includes a test chamber, a probe, and a sensor. The test chamber contains a liquid volume of test solution including an analytical reagent selected to react with the analyte. The test chamber is sealed by a pierceable membrane wall. The probe is removably positionable to pierce the membrane wall to deposit a sample in the test chamber to form a test mixture with the test solution. The sensor is positioned to detect one or more characteristics of the test mixture in the test chamber indicative of a reaction between the analyte and the analytical reagent.

SAMPLE CARRIER FOR MICROSCOPY AND OPTICAL DENSITY MEASUREMENTS

Apparatus and methods are described for determining a property of a bodily sample using a microscope and optical-density-measurement apparatus, the apparatus including a sample carrier that includes a plurality of microscopy sample chambers configured to receive a first portion of the sample and to facilitate imaging of the first portion of the sample by the microscope, each of the microscopy sample chambers having an upper and a lower surface, and having respective heights between the upper and lower surfaces that are different from each other. The sample carrier includes at least one optical-density-measurement chamber configured to receive a second portion of the sample, and to facilitate optical density measurements being performed optical-density-measurement apparatus upon the second portion of the sample. Other applications are also described.

SAMPLE CARRIER FOR MICROSCOPY MEASUREMENTS

Apparatus and methods for determining a property of a bodily sample using a microscope are described. A sample carrier includes a plurality of microscopy sample chambers configured to receive a least a portion of the bodily sample, while the sample is imaged by the microscope. Each of the microscopy sample chambers has an upper and a lower surface, and the microscopy sample chambers have respective heights between the upper and lower surfaces that are different from each other. The sample carrier defines a microscopy sample chamber inlet hole, that is fluid communication with all of the microscopy sample chambers, such as to facilitate filling of all of the microscopy sample chambers with the portion of the bodily sample, via the microscopy sample chamber inlet hole. Other applications are also described.

SAMPLE CARRIER FOR OPTICAL MEASUREMENTS

Apparatus and methods are described including a sample carrier (22) configured to carry a portion of a bodily sample, at least a portion of the sample carrier being configured to fluoresce, at least under certain conditions. An optical measurement device (24) performs optical measurements upon the portion of the bodily sample that is housed within the sample carrier (22), and at least partially photobleaches an area within the portion of the sample carrier (22) by causing the area to fluoresce. By detecting that the area within the portion of the sample carrier (22) has been photobleached, an output is generated indicating that at least a portion of the sample carrier (22) is contaminated or that optical measurements cannot be performed on the portion of the sample carrier (22), or the optical measurement device (24) is prevented from performing optical measurements upon a sample portion housed within the given portion of the sample carrier (22).

Hand-held microfluidic detection device that uses a parasitic light suppressing mechanism to reduce background noise

The present invention relates to a hand-held microfluidic detection device, comprising: a microfluidic cell (M) having at least one chamber intended to at least contain a sample; a support (S) comprising a housing for the removable attachment thereto of the microfluidic cell (M); excitation light means arranged at least in part in the support (S) to side illuminate the at least one chamber of the microfluidic cell (M) to excite the sample contained therein; an optical detector (D) configured and arranged to detect light emitted from the sample when excited with said side illumination; and a casing (C) constituting an envelope into which at least the support (S) is housed and attached.