A digital microfluidic (DMF) system, DMF cartridge, and method including integrated refractive index (RI) sensing is disclosed. The digital microfluidic DMF system and DMF cartridge may include, for example, a RI sensor (or sensor surface) directly in the droplet operations gap of a DMF cartridge. The digital microfluidic DMF system may include, for example, the DMF cartridge, one or more illumination sources, one or more optical measurement devices, and a controller. Additionally, a method of using the DMF system and DMF cartridge that includes integrated RI sensing is provided.

The present disclosure relates to a novel absorbance-based colorimetric device system, and to methods of using the novel absorbance-based colorimetric device system.

Methods to detect contaminants in a solution and applications thereof are described. Generally, solutions are printed onto a substrate and then imaged via Raman spectroscopy, which can be utilized to detect signals derived from contaminants.

Provided is a spectrophotometric device including a base plate including a first surface to accommodate a sample thereon, a rotatable plate including a second surface corresponding to and spaced a certain distance apart from the first surface, a test beam radiator connected to the first surface through a first beam guide to radiate a test beam to the sample accommodated on a beam path between the first and second surfaces, a spectrophotometer connected to the second surface through a second beam guide to analyze spectroscopic properties of the sample by analyzing a characteristic beam having passed through the sample accommodated on the beam path, and a state determiner provided near the beam path to determine whether the sample accommodated between the first and second surfaces is in a state in which analysis of optical properties is enabled.

The present invention relates to a method for analyzing and selecting a specific droplet among a plurality of droplets (4), comprising the following steps: —providing a plurality of droplets (4), —for a droplet (4) among the plurality of droplets, measuring at least two optical signals, each optical signal being representative of a light intensity spatial distribution in the droplet for an associated wavelength channel, —calculating a plurality of parameters from the optical signals, —determining a sorting class for a droplet according to calculated parameters, —sorting said droplet according to its sorting class, wherein the plurality of parameters comprises the coordinates of a maximum for each optical signal and a co-localization parameter and the at least two calculated parameters used for the determining step comprises the co-localization parameter.

A cell detection method and a cell detection device. The cell detection method includes: dividing a liquid sample into a plurality of droplets in a sample detection region so that each of the plurality of droplets includes fewer than ten cells; and performing optical detection on the plurality of droplets in the sample detection region to determine a target droplet including a target cell from the plurality of droplets.

Apparatus for performing multiple different measurements on a small specimen sample, enabling testing and diagnoses in real time at the point of care are described. The core of the apparatus includes an ultrasonic resonator cavity where acoustic resonances are used to determine the speed of sound and sound attenuation in a single droplet. Acoustic measurements are made in the reflection mode using electrical impedance of a small piezoelectric crystal transducer that operates in the thickness longitudinal mode. Combination of this technology with electromagnetic, electrical, and magnetic fields permits multiple types of measurements to be made using the same resonator cavity.

The present disclosure relates to an optical detection device that includes a measurement mechanism and a cleaning mechanism. The measurement mechanism has a first measurement unit and a second measurement unit. One of the first and second measurement units is an optical fiber emitter end and the other one of the first and second measurement units is an optical fiber receiver end. The first and second measurement units each has a measurement end face wherein a preset gap for containing a to-be-detected sample is disposed between two of the measurement end faces and the to-be-detected sample is configured to adhere to the measurement end faces of the first and second measurement units to form a suspended fluid column The cleaning mechanism has a suction tip which is disposed close to the preset gap and is configured to suck the to-be-detected sample in the preset gap.

A microfluidic device includes: first substrate, microfluidic channel layer, and second substrate; the first substrate includes light source layer including a plurality of light source structures, the light source structure includes first electrode, second electrode, and an electroluminescence module, and when being turned on, emits light passing through the microfluidic channel layer and irradiating the second substrate; the second substrate includes photoelectric detection layer including a plurality of photoelectric detection structures and driving electrode layer including a plurality of driving electrodes and a plurality of driving circuits, the photoelectric detection structure includes third electrode, fourth electrode, and photoelectric conversion module arranged therebetween, and when being turned on, generates an electrical signal according to an incident light signal; the driving circuit is configured to apply a voltage to each driving electrode such that a droplet moves in a microfluidic channel of the microfluidic channel layer.

Cell counters and methods of their use are disclosed herein. The cell counters comprise a sample mounting system that includes a base comprising a mounted lower sample surface and a cover comprising a mounted upper sample surface; a bright-field light source incorporated in the cover; an objective lens mounted below the sample mounting system; optionally, a fluorescence excitation source in optical communication with the sample mounting system; and an imaging system in optical communication with the bright-field light source and the objective lens. The mounted sample surfaces are configured for repeated use, such that disposable sample cartridges are not needed.