An arrangement for operating a biosensor emitting radiation includes an excitation light source, which generates at least one excitation radiation for the biosensor; a coupling fiber, at the entry surface of which the excitation radiation is coupled in; an optical Y-coupler, including an excitation arm, which is connected to the exit surface of the coupling fiber, a detector arm, which is connected to an optical detector, and a sensor foot, which can be connected to the biosensor. The excitation arm has a conical shape. The radiation axis of the excitation arm includes an angle in the range of 5° to 70° with the main radiation axis of the detector arm. The diameter of the excitation arm at the connecting point to the detector arm is less than two thirds the diameter of the detector arm. An arrangement for determining the glucose content blood is also provided.

A method is provided for degradation-compensated evaluation of detection signals of a sensor arrangement operating on the principle of luminescence quenching, which arrangement has a luminophore that degrades over time, an excitation radiation source, and at least one optical sensor. The luminophore radiates, in accordance with a response characteristic of the sensor arrangement, in reaction to irradiation with a predefined modulated excitation radiation and as a function of the extent of an interaction of the luminophore with a quencher substance that quenches the luminescence of the luminophore. A response radiation is detected by the at least one optical sensor. The sensor arrangement outputs a detected intensity value representing an intensity of the response radiation and a detected phase value representing a phase difference of the response radiation with respect to the modulation of the excitation radiation. A predetermined calibration value correlation is identified in consideration of the reference response characteristic.

A method and optode for determining a concentration of an analyte in a sample liquid is provided. The method comprises a radiation source, where excitation radiation is directed onto a carrier unit which is in contact with the sample liquid and has immobilized molecules of a sensor dye that is sensitive to the analyte. The excitation radiation induces luminescence radiation of the sensor dye. This radiation is detected by a radiation detector, which generates an output signal. The analyte concentration is ascertained from the detector output signal using an evaluation routine. This uses a property of the luminescence radiation on the interaction of the concentration of the analyte in the sample liquid used. The dependence of the examined property of the luminescence radiation on an indirect exchange interaction between the individual molecules of the sensor dye, which interact with each other over particles of the analyte.

The present disclosure discloses an optochemical sensor for determining a measurand correlating with a concentration of an analyte in a measuring fluid, comprising: a housing having an immersion region configured for immersing in the measuring fluid; a removable cap having a sensor spot, the removable cap removably arranged at the immersion region of the housing, wherein the sensor spot is disposed on a circumferential face; a radiation source disposed in the housing for radiating excitation radiation into the removable cap, wherein a deflection module is disposed in the removable cap as to deflect excitation radiation radiated into the removable cap; a radiation receiver disposed in the housing for receiving received radiation emitted by the sensor spot; and a sensor circuit disposed in the housing and configured to control the radiation source, receive signals of the radiation receiver, and generate output signals based on the signals of the radiation receiver.

The present disclosure provides a method for detection of an analyte in a sample, where the sample is introduced into an analytic chamber along with droplets of an emulsion or gel beads. In another aspect, the present disclosure provides designs for formulations of emulsion drops or gel beads such that they are useful for detection of analytes in a massively parallel manner. Formulations that contain specific combinations of fluorescent particles allow optical determination of the identity of each fluorescent particle. The combinations are based on particle fluorescence emission wavelength, fluorescence excitation wavelength, and particle count.

The present disclosure relates to an electrochemical sensor for determining a measurand correlating with a concentration of an analyte in a measuring fluid, comprising: a sensor membrane designed to be in contact with the measuring fluid for detecting measured values of the measurand; a probe housing which has at least one immersion region designed for immersion into the measuring fluid, wherein the sensor membrane is arranged in the immersion region of the probe housing; and a measurement circuit which is at least partially contained in the probe housing and is designed to generate and output a measurement signal dependent on the measurand, wherein the sensor membrane contains an optically detectable substance for marking the sensor membrane.

A device for monitoring a measurement object, comprising: an active unit having a light source emitting light with a wavelength spectrum and an optical detector. An optical link passes the emitted light to a at least one passive unit. Each passive unit comprises a sensor and a selector for diverting the emitted light to the sensor. The sensor comprises a luminescent material being directly or indirectly affected by the emitted light diverted by the selector. The sensor is sensitive to an external influence by the measurement object for producing a modulated signal, which is passed to said detector via the optical link. The luminescent material may be a fluorescent material, which is directly irradiated by the emitted light from the light source.

In a sensor unit, a sensor element having an optical behavior that depends on at least one analyte is in diffusive contact with an auxiliary medium, which is present in a reservoir in the sensor unit, via a membrane. The reservoir and the membrane, on the one hand, and sensor element, on the other hand, can be removed from one another in order to place the sensor unit in a measurement state. The auxiliary medium can serve to wet the sensor element during storage of the sensor unit or also for calibrating the sensor element.

The present disclosure relates to a device for measuring a first analyte concentration and a second analyte concentration in a measuring medium, the device including: a sample cell; a first light source unit; a first detector unit; a functional element; a second light source unit; a second detector unit; and a control unit adapted to analyze a detected first light for determining a first value representing the concentration of the first analyte in the measuring medium and adapted to analyze a detected third light for determining a second value representing the concentration of the second analyte in the measuring medium. A method of using the device is also disclosed.

An optochemical sensor unit including: an optical waveguide; a transmitting unit for emitting a first transmission signal for exciting a luminophore; a receiving unit for receiving a received signal comprising a signal component emitted by the excited luminophore; a measuring chamber for receiving a fluid, wherein the fluid includes magnetic microspheres; a membrane arranged between the measuring chamber and a measuring medium for exchanging an analyte between the measuring medium and the fluid in the measuring chamber, wherein the measuring diaphragm is impermeable to the magnetic microspheres; and an electromagnet for attracting magnetic microspheres to a sensor membrane with a fluid-contacting surface and/or to a fluid-contacting surface of the optical waveguide, or to a surface of a transparent substrate layer of the optical sensor unit that is connected to the optical waveguide.