Disclosed herein are embodiments of sensor devices comprising a sensing component able to determine the presence of, detect, and/or quantify detectable species in a variety of environments and applications. The sensing components disclosed herein can comprise MOF materials, plasmonic nanomaterials, redox-active molecules, a metal, or any combinations thereof. In some exemplary embodiments, optical properties of the plasmonic nanomaterials and/or the redox-active molecules combined with MOF materials can be monitored directly to detect analyte species through their impact on external conditions surrounding the material or as a result of charge transfer to and from the plasmonic nanomaterial and/or the redox-active molecule as a result of interactions with the MOF material.

This disclosure provides for methods and reagents for rapid multiplex RPA reactions and improved methods for detection of multiplex RPA reaction products. In addition, the disclosure provides new methods for eliminating carryover contamination between RPA processes.

A method is provided for degradation-compensated evaluation of detection signals of a sensor arrangement operating on the principle of luminescence quenching, which arrangement has a luminophore that degrades over time, an excitation radiation source, and at least one optical sensor. The luminophore radiates, in accordance with a response characteristic of the sensor arrangement, in reaction to irradiation with a predefined modulated excitation radiation and as a function of the extent of an interaction of the luminophore with a quencher substance that quenches the luminescence of the luminophore. A response radiation is detected by the at least one optical sensor. The sensor arrangement outputs a detected intensity value representing an intensity of the response radiation and a detected phase value representing a phase difference of the response radiation with respect to the modulation of the excitation radiation. A predetermined calibration value correlation is identified in consideration of the reference response characteristic.

A component measurement device for measuring a component of interest in blood on a basis of optical characteristics of a mixture containing a color component produced by a color reaction between the component of interest in the blood and a reagent includes: a first light source configured to emit first irradiation light of a first predetermined wavelength to the mixture; and a second light source configured to emit second irradiation light of a second predetermined wavelength to the mixture, the second irradiation light to be used for estimation of a noise amount contained in a measured value of absorbance of the mixture measured by using the first irradiation light of the first light source, the noise amount being derived other than from the color component.

The present invention relates a sensor assembly for analyzing a complex fluid sample. The sensor assembly comprises a sample chamber for holding the complex fluid sample, the sample chamber being defined by chamber walls and having an inlet and an outlet defining a direction of flow from the inlet towards the outlet for fluid handling in the sample chamber. The sample chamber comprises a first sample space and a second sample space. The second sample space comprises a porous membrane sensor element for detecting an analyte in a continuous fraction of the complex fluid sample. The porous membrane sensor element comprises a porous membrane with a front side defining a sensor surface for contacting the fluid sample, the sensor surface facing towards the second sample space, the porous membrane comprising pores extending from respective openings at the sensor surface into the porous membrane. The pores are configured with regard to the analyte for diffusive fluid communication with the second sample space. The sample chamber further comprises a flow-perturbing element arranged upstream of the second sample space, between the first sample space and the second sample space.

Among other things, this application describes systems and methods for detecting gas using a wide band light source, and at least two narrow band light sensors, wherein each sensor may be operable to detect light at a different range of wavelengths. Additionally, the gas detector device may comprise a color changing indicator operable to react with gas in the air to change color, wherein different gases may react to create different colors, and wherein the sensors detect light reflected by the color changing indicator from the wide band light source. The gas detector device may comprise a processor in communication with the at least two light sensors operable to receive detected reflected wavelength information from the light sensors, and determine the type of gas that reacted with the color changing indicator based on the color detected by the sensors, wherein each color may be associated with a different type of gas.

Systems and methods to analyzes images of lateral flow assays are disclosed herein. An example image analysis system includes processor circuitry to (a) determine whether a format of an image of a lateral flow assay device satisfies a format threshold, (b) in response to determining the format of the image satisfies the format threshold, determine whether the lateral flow assay device in the image is authentic, (c) in response to determining the lateral flow assay device is authentic, determine whether a position of the lateral flow assay device in the image satisfies a position threshold, (d) in response to determining the position of the lateral flow assay device satisfies the position threshold, analyze the image to determine the result of the diagnostic test, and (e) abort the sequence of the operations during performance of the sequence of operations at the time any one of operations fails.

A microfluidic sensor for the detection of analytes in objects includes a contact surface that may be attached to a surface of the object, an inlet hole in the contact surface for the entry of fluids emitted by the object, and a first reservoir which stores an ionic fluid in the form of a polymer matrix. The polymer matrix includes a reactive substance which changes colour when it enters into contact with the analytes of the fluids emitted by the object. It further includes at least one first microfluidic duct which connects the inlet hole to the first reservoir. A system for the detection of analytes, a method for the manufacture of the microfluidic sensor and the use of the microfluidic sensor for the detection of analytes in works of art are also related.

The present disclosure relates to a microfluidic device for measuring one or more parameters in a fluid sample, which includes a sample microfluidic channel disposed on a solid substrate, a reagent microfluidic channel disposed on a solid substrate, a mixing microfluidic channel disposed on a solid substrate, and an optical reading window located downstream of the mixing microfluidic channel, through which a response indicative of the parameter(s) change can be measured optically. The present disclosure also relates to an apparatus for measuring one or more parameters in a fluid sample which includes the microfluidic device as well as a method for measuring one or more parameters in a fluid sample through the device or the apparatus.

Stabilized indicator compositions, and systems and methods using the same are described. In embodiments the stabilized indicator compositions include a solvent, an indicator, a stabilizer for the indicator, and optionally a buffer. In embodiments the indicator is or includes N, N-diethyl-p-phenylene diamine (DPD). Systems and methods utilizing the stabilized indicator composition to determine an amount of at least one constituent in a test sample (e.g., water) are also described. In embodiments, the systems and methods remove the stabilizer from the stabilized indicator composition to produce a fluid flow containing un stabilized indicator, which is then combined with a fluid from a sample source to form a test sample for analysis.