An autosampler is switched selectively between an injecting mode where a sampling flow path is incorporated into an analysis flow path of a liquid chromatograph and a loading mode where the sampling flow path is not incorporated into the analysis flow path and injects a sample into the analysis flow path at a position farther upstream than a separation column by being switched to the injecting mode with the sample held in the sampling flow path, and includes a clog determiner configured to acquire a sending liquid pressure of a liquid sending pump that sends a mobile phase in the analysis flow path, obtain a variation value of the liquid sending pressure when the injecting mode and the loading mode are switched and determine presence or absence of a clog in a system incorporated into the analysis flow path in the injecting mode based on the obtained variation value.

Described is a dual mode sample manager for a liquid chromatography system. The dual mode sample manager includes a sample needle, a sample loop, a metering pump, a needle seat and first and second valves. Each valve is configurable in two valve states to enable two modes of operation. In one mode, sample acquired and stored in the sample needle is injected into a chromatography system flow and, in the other mode, sample acquired through the sample needle and stored in the sample loop is injected into the chromatography system flow. The automated switching of the sample manager between the two modes of operation avoids the need for maintaining two separate liquid chromatography systems or manual reconfiguration of a chromatography system for users desiring the capability of both modes of operation.

Valve assemblies are described that provide magnetic coupling between a valve actuator and a valve body housing the valve rotor and stator. A valve assembly embodiment, includes, but is not limited to, a valve body, the valve body including at least one magnet, and a rotor and a stator configured to define a plurality of fluid flow passageways; a valve actuator configured to drive the rotor via a drive shaft; and an actuator mount coupled to the valve actuator and configured to magnetically couple with the at least one magnet of the valve body to magnetically couple the valve body and the valve actuator.

A method for collecting a sample for sample analysis includes drawing a first portion of the sample into a sample storage portion of a chromatography system while the chromatography system is in a first configuration. The method further comprising switching the chromatography system to a second configuration; sealing an end of a sample pick-up needle and draining a portion of a liquid from the second tubing; switching the chromatography system to a third configuration; drawing a second portion of the sample into the sample storage portion of the chromatography system; switching the chromatography system to an injection configuration; and fluidly connecting the sample storage portion to the chromatography column and supplying the first portion of the sample and the second portion of the sample from the sample storage portion to the chromatography column.

Valve with two-piece stator assembly for use with liquid chromatography or other analytical systems. A separate and removable stator plate is provided with a mounting device to provide a two-piece stator assembly. The mounting device is adapted on one side to engage and contact the stator plate, and on the other side includes a plurality of ports for fluidic connections which are in fluid communication with fluid passageways in the stator plate.

An injector is configured for injecting a fluidic sample from an injector path into a mobile phase in a separation path between a fluid drive and a sample separation unit of a sample separation device. The injector includes a control unit configured for generating a first overpressure in a blocked first partial path of the injector path by a first pressure source, for generating a second overpressure in a blocked second partial path of the injector path by a second pressure source, for subsequently fluidically coupling the first partial path with the second partial path for generating an expansion stroke for releasing a gas bubble in the injector path, and for rinsing the released gas bubble from the injector path.

A sample delivery system for liquid chromatography is provided. The sample delivery system includes: a sample receptacle; a sample aspiration cannula for aspirating a sample located in the sample receptacle, the sample aspiration cannula being directed using a drive in a direction towards the sample receptacle so that a tip at a distal end of the sample aspiration cannula is immersed in the sample; and a guide element for the sample aspiration cannula provided above the sample receptacle, the guide element being designed as a washing device. The sample aspiration cannula can be retracted using the drive at least so far from the sample receptacle such that the distal end of the sample aspiration cannula may be cleaned in the washing device.

An ion chromatography system includes a separation column configured to separate components of a solution; a non-destructive detector; and a concentrator configured to capture components of a check standard after they leave the conductivity non-destructive detector; and release the components of the check standard to the separation column.

A controller (50) of a liquid chromatograph (1) is configured to execute, as an analysis operation in an analysis unit (3), a sample injection step of bringing a high-pressure valve (10) into a loading state, sucking a sample from a tip of a needle (12) to hold a sample in a sampling channel (2), then connecting the sampling channel (2) to an injection port (16) and bringing the high-pressure valve (10) into an injecting state, and supplying a mobile phase from a liquid supplier (6), thereby injecting a sample held in the sampling channel (12) into an analysis channel (4), and an analysis step of separating components of a sample injected into the analysis channel (4) in a separation column (14) by bringing the high-pressure valve (10) in the loading state and supplying the mobile phase from the liquid supplier (6) after the sample injection step is ended. In a case where at least a predetermined condition is satisfied, after the analysis step is ended, the controller is configured to execute, as the analysis operation, a system cleaning step of cleaning a liquid flowing route from the sampling channel (2) to the analysis channel (4) by connecting the sampling channel (2) to the injection port (16) and bringing the high-pressure valve (10) into the injecting state, and supplying the mobile phase and/or a cleaning liquid from the liquid supplier (6).

A multiple channel selector valve includes a stator and a rotor that is rotatable with respect to the stator. The rotor face includes first and second fluid flow paths for transferring fluids to selected sets of passages in the stator. The fluid flow paths in the rotor face are specifically configured to accommodate high fluid flow rate regimes while reducing flow restriction.