Described is a method for determining a dwell volume of a liquid chromatography system and a liquid chromatography system that can determined the system dwell volume. The method includes mixing a flow of a first solvent with a flow of a second solvent to form a solvent mixture. The flows of the first and second solvents are decreased and increased, respectively, to generate a gradient composition. A system pressure of the liquid chromatography system is measured to determine a pressure trace defined as the measured system pressure as a function of time. The dwell volume of the system is determined from a time delay determined between the gradient composition at the mixing location and the pressure trace. The method can be performed with a liquid chromatography system having a chromatographic column or a flow restrictor used in place of the chromatographic column.

Described is a method for determining a dwell volume of a liquid chromatography system and a liquid chromatography system that can determined the system dwell volume. The method includes mixing a flow of a first solvent with a flow of a second solvent to form a solvent mixture. The flows of the first and second solvents are decreased and increased, respectively, to generate a gradient composition. A system pressure of the liquid chromatography system is measured to determine a pressure trace defined as the measured system pressure as a function of time. The dwell volume of the system is determined from a time delay determined between the gradient composition at the mixing location and the pressure trace. The method can be performed with a liquid chromatography system having a chromatographic column or a flow restrictor used in place of the chromatographic column.

A liquid chromatograph includes: an analysis column; a sample loop that temporarily contains a mixed liquid of a sample and a mixture solvent; and a passage switch valve capable of switching a passage between a load position where the mixed liquid is temporarily held in the sample loop and an injection position where the mixed liquid held in the sample loop is sent to the analysis column. In the liquid chromatograph, a specific passage is formed in each of the load position and the injection position.

A liquid chromatograph includes: an analysis column; a sample loop that temporarily contains a mixed liquid of a sample and a mixture solvent; and a passage switch valve capable of switching a passage between a load position where the mixed liquid is temporarily held in the sample loop and an injection position where the mixed liquid held in the sample loop is sent to the analysis column. In the liquid chromatograph, a specific passage is formed in each of the load position and the injection position.

A chromatography system comprising at least two pumps, a first pump which is connectable or connected with a liquid reservoir for a first fluid, and a second pump which is connectable or connected with a liquid reservoir for a second fluid, wherein the pump outlet lines from the first pump and the second pump are connected with a connection piece and, viewed in the direction of flow, a chromatography column is provided downstream of this connection piece, wherein, viewed in the direction of flow, an addition unit is provided upstream of the connection piece and a mixer switching valve and a mixer switchable by way of the mixer switching valve are provided between the connection piece and chromatography column, wherein the mixer switching valve has at least two switching positions, wherein the mixer is connectable in a first position and the mixer is bypassable in a second position.

A chromatography method in which the system is used and a conversion kit for converting a high-performance liquid chromatography system into a chromatography system for supercritical fluid chromatography are also disclosed.

A test device is provided that can comprise: a housing accommodating a chromatography support, wherein the housing comprises: a supporting part that supports a container accommodating a liquid used for chromatography. A method is provided for performing chromatography using the test device.

A test device is provided that can comprise: a housing accommodating a chromatography support, wherein the housing comprises: a supporting part that supports a container accommodating a liquid used for chromatography. A method is provided for performing chromatography using the test device.

Exemplary embodiments provide computer-implemented methods, mediums, and apparatuses configured to provide an interactive analytical method debugger for an analytical laboratory system. The analytical laboratory system may include a laboratory analytical device with a number of settings, parameters, etc. The laboratory analytical device may process a sample according to an analytical method that (among other things) defines a configuration for the device. The settings for the method may be organized into categories. The interactive debugger identifies problems with the method (e.g., incompatibilities, values out of range, etc.) and automatically allow the user to view the category of the method that is relevant to addressing the issue. Possible solutions may be proposed in the debugger interface, allowing the user to quickly identify and address the problem. Embodiments are particularly well-suited to situations where a method is ported from an old device to a new device.

Exemplary embodiments provide computer-implemented methods, mediums, and apparatuses configured to provide an interactive analytical method debugger for an analytical laboratory system. The analytical laboratory system may include a laboratory analytical device with a number of settings, parameters, etc. The laboratory analytical device may process a sample according to an analytical method that (among other things) defines a configuration for the device. The settings for the method may be organized into categories. The interactive debugger identifies problems with the method (e.g., incompatibilities, values out of range, etc.) and automatically allow the user to view the category of the method that is relevant to addressing the issue. Possible solutions may be proposed in the debugger interface, allowing the user to quickly identify and address the problem. Embodiments are particularly well-suited to situations where a method is ported from an old device to a new device.

The measurement of glutaraldehyde-based biocides in seawater without the use of a derivatization agent. The measurement of glutaraldehyde-based biocides in seawater may be performed without additional components to reduce background interferences. The concentration of a glutaraldehyde-based biocides in a seawater sample is determined using reversed phase liquid chromatography and a gradient mobile phase of acetonitrile and deionized water. Systems for determining the concentration of glutaraldehyde-based biocide in a seawater injection system are also provided.