Provided are a method of and an apparatus for formulating a multicomponent drug capable of surely making a multicomponent drug meeting criteria for productization with high accuracy into a product. The method and apparatus obtain a chromatogram from an extract or a base of a multicomponent drug, evaluate whether the base meets the criteria for productization based on the obtained chromatogram with high accuracy, and subject the base determined in the high-accuracy evaluating as an accepted one meeting the criteria to dosage form processing, to produce a formulated drug having a given dosage form. The high quality evaluation is realized by performing peak assignment of a target fingerprint obtained from a chromatogram to a reference fingerprint with high accuracy.

An apparatus detects gas in a high-voltage device, which is filled with an insulating medium. The apparatus has: an inlet configured for introducing a carrier gas; an outlet configured for discharging the carrier gas; at least one gas sensor configured to detect a gas; a first pump configured to convey the carrier gas in the apparatus; a membrane which comprises at least one semipermeable basic material, which is at least partially surrounded by the insulating medium, and which is arranged to be at least partially subjected to an incident flow of the carrier gas; a second pump configured to convey the carrier gas into the apparatus and out of the apparatus; and a separating column, which is arranged before the gas sensor. The gas sensor is a sensor array.

The present disclosure describes a computer implemented method, a system, and a computer program product of controlling the purification of a macromolecule solution via real-time multi-angle light scattering.

The measurement of glutaraldehyde-based biocides in seawater without the use of a derivatization agent. The measurement of glutaraldehyde-based biocides in seawater may be performed without additional components to reduce background interferences. The concentration of a glutaraldehyde-based biocides in a seawater sample is determined using reversed phase liquid chromatography and a gradient mobile phase of acetonitrile and deionized water. Systems for determining the concentration of glutaraldehyde-based biocide in a seawater injection system are also provided.

A method for identifying converters from tobacco seedling population. The method includes: 1) sowing and cultivating tobacco seeds to be identified for 45-55 days; sampling a plurality of leaf disks from each of 45-55 days old seedlings; 2) incubating the plurality of leaf disks of each seedling in a sealed container at 37° C. for 10-12 hours, thereby obtaining a plurality of incubated tobacco leaves of each seedling; 3) immersing the plurality of incubated tobacco leaves of each seedling in an extractant, extracting alkaloids and obtaining an extract of each seedling; 4) analyzing the amounts of nicotine and nornicotine in the alkaloids extract of each seedling; and 5) automatically recognizing peaks of the alkaloids extract of each seedling, and calculating the percent nicotine conversion (PNC) and the pseudo percent nicotine conversion (PPNC).

The present specification relates to a method for analyzing a deuterated compound by chromatography, and manufacturing an organic light emitting device using a deuterated compound selected based on the analyzed data.

In one aspect, a method for automated analysis of samples from a bioreactor is provided herein, the method including: drawing at least one sample from a bioreactor; pressurizing the drawn at least one sample into a sample flow; purifying at least one target protein in the sample flow using a first liquid chromatography apparatus to create a purified sample flow; splitting the purified sample flow into a purified sample fraction flow and an effluent flow; and, analyzing the at least one target protein in the purified sample fraction flow using a second liquid chromatography apparatus. Advantageously, the subject invention provides for an automated two-step liquid chromatography process utilizing first dimension liquid chromatography for purification and second dimension liquid chromatography for analysis.

The present disclosure provides a process for assaying stability of monovalent and/or multivalent, liquid and lyophilized polysaccharide protein conjugate vaccine compositions using HPLC-SEC method. The method provides stability analysis (lot to lot) of polysaccharide protein conjugate vaccine with respect to aggregation profile, molar mass distribution and/or molecular size distribution, and data can be utilized for quality control during storage and batch release. The method is performed in the presence of multiple carrier proteins, free polysaccharides and excipient, without any interference of said components.

The disclosure includes a gas chromatograph for underground use comprising a fixing board. In some embodiments, the gas chromatograph for underground use includes a power connection socket, at least one three-way solenoid valve, a quantitative loop, an analysis module, a communication main board, a data transmission device, a sample injection membrane valve, and a gas injection pump detachably coupled to the fixing board. In some embodiments, the quantitative loop and the sample injection membrane valve are arranged and configured to couple to at least one of the at least one three-way solenoid valves.

Provided herein are high-pressure liquid chromatography (HPLC) methods for detecting multi-specific molecule formation after a multi-specific molecule manufacturing or development process. The HPLC methods provide fast, quantitative, real-time processing of multi-specific molecule formation.