Embodiments described herein relate to an apparatus for positioning and securing an excised biological tissue specimen for imaging and analysis. In some embodiments, an apparatus includes a sample bag defining an inner volume configured to receive a biological tissue sample, and a sealing member coupled to the sample bag. An imaging window is disposed and configured to be placed in contact with at least a portion of the biological tissue sample, and a positioning member is coupled to the imaging window and is configured to be disposed against the sealing member to substantially seal the inner volume. The positioning member includes a vacuum port disposed and configured to be aligned with a vacuum source to withdraw air from the inner volume of the sample bag.

A system is capable of detecting substrates and can differentiate between zero, one, or multiple transparent or semi-transparent substrates in a stack. The system can include an optical sensor, an optically anti-reflective element, and a detector. The optical sensor outputs light towards the optically anti-reflective element. The light detector is positioned to detect light from the light source that is reflected by substrates, if any, positioned within a detection zone between the optically anti-reflective element and the detector.

Systems and methods for automated cap removal with an autosampler system are described. In an aspect, an autosampler system includes, but is not limited to, a sample rack; a sample vessel stabilizer configured to transition the sample rack between a load/unload state and a lock state; an uncapper supported by a first z-axis support; and a sample probe supported by a second z-axis support, wherein the uncapper is configured to remove a cap from a sample vessel held by the sample rack when the sample rack is in the lock state, and wherein the uncapper is configured to change the position of the removed cap to permit access to an interior of the sample vessel by the sample probe without removing the sample vessel from the sample rack.

The present invention relates to a fluid transport system for an automated slide treatment apparatus for treating one or more tissue samples disposed on slides, whereby the slide treatment apparatus includes a plurality of slide treatment modules arranged to receive ones of the slides, and the fluid transport system includes a fluid dispensing robot configured by a controller to dispense a plurality of reagents to said ones of the slides received in the slide treatment modules to treat said one or more tissue samples respectively.

A method for the distribution of supports includes positioning a plurality di tubular containers, each containing a plurality of supports impregnated with antibiotics and stacked, in a corresponding plurality of seats of a dispenser. Extraction of at least a first support from a first container, is performed using an extractor, moving the first support between a first position inside of the first container and a second position extracted from the first container. Collection of the first support from the second position by a collector is performed. Transportation of the first support towards a culture plate by the collector is performed, the first support is held at least at the end of extraction, in substantial correspondence of the second position and/or during collection and/or of transportation through the collector, a vacuum is created between the first support and a striking surface using a vacuum holder.

There are provided a vacuum transfer system installed in an microscope to prevent oxidation of a sample and a sample measurement method using the vacuum transfer system. The vacuum transfer system according to an embodiment is a vacuum transfer system installed in an microscope to prevent oxidation of a sample, and includes a housing having an open surface, wherein the surface has a coupling element for attaching or detaching to/from the microscope, and an inside of the housing is kept closed from outside as the housing is coupled with the microscope through the coupling element, a gas inlet through which an inert gas is introduced into the housing, a gas outlet through which an active gas in the housing exits with the introduction of the inert gas into the housing, and at least one glove formed to be connected with the inside of the housing.

A gripper having a mechanical coupling that can be connected to a pipetting tube, at least one fluid channel extends from the coupling and a negative pressure can be transmitted, the gripper having at least one suction cup that is connected to the coupling through the at least one fluid channel as a result of which the negative pressure can be transmitted from the coupling to the at least one suction cup, and the at least one suction cup in the intended use position of the gripper is aligned such that a rim of a suction cup of the at least one suction cup is aligned in a substantially vertical plane.

In a device for coupling a cartridge for a lab-on-a-chip analysis device, the cartridge has at least one pneumatic port and at least one reagent chamber. The device has a receiving region and a clamping unit. The receiving region is shaped to receive the cartridge. The clamping unit includes a pneumatic interface for pneumatically contacting the pneumatic port and a punch for insertion into the reagent chamber. The clamping unit is arranged adjacent to the receiving region and is designed to perform a first translatory motion toward the receiving region in order to bring the pneumatic interface into contact with the pneumatic port. Furthermore, the clamping unit is designed to perform a second translatory motion toward the receiving region following the first translatory motion in order to insert the punch into the reagent chamber.

Systems and methods are described for integrated sample container cover removal and sample probe positioning. In an example implementation, an autosampler system includes, but is not limited to, a z-axis support rotatable about a z-axis of an autosampler deck; a sample probe support structure coupled to the z-axis support, the sample probe support structure configured to hold a sample probe to withdraw a fluid-containing sample held within a sample container supported by the autosampler deck; and a sample cap remover coupled to the z-axis support in an orientation that is rotationally offset from the z-axis support with respect to the sample probe support structure, the sample cap remover configured to lift a cap from the sample container to provide access to an interior of the sample container by the sample probe supported by the sample probe support structure.

The present invention relates to a fluid transport system for an automated slide treatment apparatus for treating one or more tissue samples disposed on slides, whereby the slide treatment apparatus includes a plurality of slide treatment modules arranged to receive ones of the slides, and the fluid transport system includes a fluid dispensing robot configured by a controller to dispense a plurality of reagents to said ones of the slides received in the slide treatment modules to treat said one or more tissue samples respectively.