A fluid disposing system includes a centrifugal separator that centrifugally separates a liquid that is supplied, a reagent injecting apparatus coupled to the centrifugal separator and that injects a reagent into the centrifugal separator, a reagent supply module that supplies the reagent to the reagent injecting apparatus and a pipetting module provided on an upper side of the centrifugal separator and that feeds the fluid to the centrifugal separator.

According to one embodiment, an automatic analyzer includes dispenser, measurer, thermostat, cooler and cleaner. Dispenser dispenses a specimen and a reagent into a reaction vessel. Measurer measures a solution mixture of the specimen and the reagent in the vessel. Thermostat heats the mixture to a first temperature at which thermoresponsive polymers contained in the reagent aggregate. Cooler cools a cleaning fluid used to clean the vessel to a second temperature lower than the first temperature, at which the polymers contained in the reagent disperse. Cleaner cleans the vessel from which the mixture has been drained, using the cooled fluid.

An apparatus configured to receive particles in a liquid includes: a housing comprising a housing inlet and a housing outlet; and a mesh located in the housing between the housing inlet and the housing outlet, the mesh having spaces greater than a greatest transverse dimension of the particles. The apparatus operates to break up agglomerates of the particles, such as agglomerates of magnetic particles. Other systems and methods of receiving and transferring liquids containing particles having a propensity to agglomerate are disclosed, as are other aspects.

Provided is an automatic analyzer that reduces a risk of damage due to contact with a stirring paddle during maintenance and the like, and realizes miniaturization and simplification. A cleaning tank 181 configured to clean the stirring paddle, a standby position 182 configured to make the stirring paddle which is juxtaposed to the cleaning tank wait, and an inflow port 183 configured to flow cleaning water into the cleaning tank are provided, and the standby position 182 is arranged so that the cleaning water overflowing from the cleaning tank 181 overflows 194 to the standby position 182.

The present disclosure relates to a cleaning device and a chemiluminescence detector. A cleaning device is provided with a cup inlet station and a cup outlet station, wherein the cleaning device comprises a pedestal, a plurality of magnetic adsorption components, a turntable arranged on the pedestal, and a primary cleaning mechanism arranged on the pedestal, wherein each of the plurality of magnetic adsorption components comprises a plurality of magnets; magnetic adsorption heights of a plurality of magnets of the first magnetic adsorption component are equal and are recorded as A; magnetic adsorption heights of a plurality of magnets of the middle magnetic adsorption component are equal and are recorded as B, and B>A.

The present invention is an automated separation system comprised of a liquid handling device and one or more pipette tip columns, wherein the liquid handling device is equipped with two or more nozzles arranged to respectively receive a pipette tip column comprising separation media. Further, the system includes means for applying either high positive or negative pressure to the column inside chamber above the column bed, enabling aspiration and dispensing into and out of each pipette tip column. To enable sealing to the pressures used to move liquid through the column bed without inadvertently ejecting the column from the nozzle during the separation process, each nozzle has been provided with at least one annular protrusion arranged to engage with the inside of a substantially evenly tapered pipette tip column, without any corresponding recess. Each nozzle may be provided with slide ejector to enable the removal of a pipette tip column.

A separating apparatus of biosubstance and a separating method of the same are provided. The separating method includes: providing a controller to select a positive separation process or a negative separation process to execute according to types of target biosubstances; providing a pipette pump to inject a first magnetic bead reagent or a second magnetic bead reagent into a sample according to the selected separation process, such that first immunomagnetic beads of the first magnetic bead reagent or second immunomagnetic beads of the second magnetic bead reagent are used for binding to the target biosubstances; providing a magnetic separation rack to enrich the target biosubstances so as to separate the target biosubstances and non-target biosubstances; and providing the pipette pump to separate the target biosubstances and the non-target biosubstances.

Provided herein are apparatuses and systems for mixing liquids and suspensions that include vessels with structures that improve mixing while not contacting liquid delivery components. The apparatuses and systems can include a motor drive that allows speed and directional control of rotation of the vessel. The apparatuses and systems can include one or more magnets for separating magnetic beads in a suspension. Also provided are methods using said apparatuses and systems for mixing and separation processes.

Magnetic beads having cell components of interest are translated between a sequence of processing wells in a tray without need for pipetting. The circular tray contains one or more sequences of wells each interconnected by a respective channel. The tray is rotated about a central axis and a magnet, an agitator, and a heater provided external to the tray enable magnetic bead translation, mixing, and incubation, respectively. The magnet proximate a well forms a cluster of beads. Manipulation of the tray in rotation and elevation results in translation of the cluster from one well, through a channel, and into an adjacent well. The well containing a cluster may be rotationally positioned in front of the agitator, the agitator extended into contact with the well, followed by mechanical agitation. The heater, disposed beneath the tray, may accept a well lowered thereto for selective heating.

A method for preparing for preparing a solution comprising a plurality of particles in a vial is disclosed. The method includes agitating the vial at a first predetermined mixing speed. The method also includes dispersing, into the vial, during the agitating, a first volume of buffer solution at a first predetermined dispensing rate to suspend the plurality of particles in the solution, wherein particles of the plurality of particles comprise a unique identifying feature.