G01N2035/0437

Dilution Method and Dilution Apparatus
20230046531 · 2023-02-16 ·

Disclosed are a dilution method and a dilution apparatus. The dilution method includes: adding a sample into a first reactor at a first station of a supply unit; transferring the first reactor to a fifth station of a transit apparatus, and receiving a second reactor at the first station of the supply unit; adding a diluent into the first reactor at the fifth station to obtain a diluted sample; uniformly mixing the diluted sample in the first reactor; transferring the first reactor from the transit apparatus to a dilution transport apparatus; transferring part of the diluted sample in the first reactor to the second reactor; transferring the second reactor to the fifth station of the transit apparatus, and continuing to add the diluent into the second reactor; and uniformly mixing substances in the second reactor. The dilution apparatus includes the supply unit and the transit apparatus.

AUTOMATED ANALYZER AND LIQUID RESERVOIR

Provided are an automated analyzer for analyzing a substance contained in an unknown sample and a liquid reservoir, the analyzer and the reservoir being capable of saving users' operation without remarkably increasing the number of components. A flow path outlet of an overflow portion of the liquid reservoirs projects closer to the inner circumferential side of a drain flow path than to an inner circumferential surface side of an outer wall of the drain flow path serving as a destination to which liquid overflows. In addition, the flow path outlet projects so as to come into contact with an outer wall of the inner pipe. The flow path outlet of the overflow portion projects into the drain flow path so as to be located below an upper end of the outer wall of the drain flow path.

FULLY-AUTOMATIC CHEMILUMINESCENCE IMMUNOASSAY ANALYZER

Disclosed is a fully-automatic chemiluminescence immunoassay analyzer, which comprises a base, a reaction cup conveyance module, a robot-arm sample injection module, an incubation module, a manipulator and transit module, a magnetic-separation cleaning module, and a detection module are mutually independently integrated on the base. The reaction cup conveyance module is used for conveying a reaction cup to a pre-determined position; the manipulator and transit module carries the reaction cup into the incubation module, to incubate the reaction cup for a constant-temperature reaction; the reaction cup in the incubation module is carried to the magnetic-separation cleaning module for magnetic-adsorption cleaning; and the reaction cup after cleaning is carried by the manipulator and transit module to the detection module for detection. A plurality of manipulators and a plurality of transit devices may be disposed as required, to link the mutually independent functional parts of the modules. Further, the instrument may be equipped with detection modules and process modules of various detection platforms, which cooperate with the manipulator and transit module to realize diverse detection in a table-top production line manner.

Method for performing a magnetic separation procedure

A method for performing a magnetic separation procedure that includes transporting a receptacle containing a fluid medium to a first location of a system, where the fluid medium contains both a sample material and a suspension of magnetically-responsive solid supports. At the first location, the fluid medium is exposed to a first magnetic field for a first dwell period, thereby isolating the solid supports within the receptacle, where no portion of the fluid medium is removed from the receptacle at the first location. The receptacle is then transported from the first location to a second location of the system, where the fluid medium is exposed to a second magnetic field for a second dwell period. Following the second dwell period, at least a portion of the fluid medium is removed from the receptacle. A suspension fluid is then dispensed into the receptacle, and the contents of the receptacle are agitated to suspend the solid supports within the suspension fluid.

Double bag for automated analysis device
11511280 · 2022-11-29 · ·

Double bag having a first compartment containing a composition to be distributed and a second compartment for receiving a used fluid, a first bag connector communicating with the first compartment and serving to empty the latter, and a second bag connector communicating with the second compartment and serving to fill the latter.

Cleaning device and chemiluminescence detector

The present disclosure relates to a cleaning device and a chemiluminescence detector. A cleaning device is provided with a cup inlet station and a cup outlet station, wherein the cleaning device comprises a pedestal, a plurality of magnetic adsorption components, a turntable arranged on the pedestal, and a primary cleaning mechanism arranged on the pedestal, wherein each of the plurality of magnetic adsorption components comprises a plurality of magnets; magnetic adsorption heights of a plurality of magnets of the first magnetic adsorption component are equal and are recorded as A; magnetic adsorption heights of a plurality of magnets of the middle magnetic adsorption component are equal and are recorded as B, and B>A.

Cleaning module, sample analyzer with cleaning module and cleaning method

A cleaning module, a sample analyzer with the cleaning module and a cleaning method. Wherein, the cleaning module may include a disk body assembly and a cleaning assembly. The disk body assembly may include a disk body, the cleaning assembly and the disk body may move relatively, and the disk body and the cleaning assembly complete extraction of waste fluid and cleaning on a path of moving relatively.

METHOD OF PRODUCING REACTION UNIT, KIT FOR PRODUCING REACTION UNIT, AND METHOD OF MEASURING DETECTION TARGET SUBSTANCE
20220364974 · 2022-11-17 ·

A method of producing a reaction unit includes (a1) preparing a first substrate which is a substrate having a first surface and a second surface and of which at least the first surface is composed of polypropylene, and which has one or more through-holes that penetrate from the first surface to the second surface, and a second substrate which is a substrate having a first surface and a second surface and of which at least the first surface is composed of at least one selected from the group consisting of cycloolefin polymers and cycloolefin copolymers, and which has a track region in which concave parts and convex parts are alternately formed on the first surface; (b1) applying a photocurable composition around an opening of the through-hole on the first surface of the first substrate; (c1) emitting light to the photocurable composition applied around the opening of the through-hole to form a cured resin layer in which the photocurable composition is cured; and (d1) forming a well having the track region as a bottom surface and the through-hole as a side surface, which is a well formed by bringing the cured resin layer formed on the first surface of the first substrate into close contact with the first surface of the second substrate after the process (c1).

CONFIGURABLE WASH PROCESS FOR A SAMPLE ANALYZER

A configurable washing arrangement (176) washes away at least unreacted components (230, 630) of patient samples (224, 624) from a reaction cell (220, 320) with a multiple number of wash actions (206, 210, 606). The configurable washing arrangement is suitable for use with an immunoassay diagnostic system (100) and washes the reaction cell within a predetermined timed sequence (Tww). The number of the wash actions correspond with an assay type of a plurality of assay types (200, 600). The various number of wash actions may be selected without compromising overall process speed. The immunoassay diagnostic system is configured to perform the plurality of the assay types and thereby detect analytes (244, 644) in patient samples (224, 624) by at least combining each of the patient samples with at least one reagent (216, 232, 616) in the reaction cell.

METHOD FOR PERFORMING A MAGNETIC SEPARATION PROCEDURE
20230095546 · 2023-03-30 ·

A method for performing a magnetic separation procedure that includes transporting a receptacle containing a fluid medium to a first location of a system, where the fluid medium contains both a sample material and a suspension of magnetically-responsive solid supports. At the first location, the fluid medium is exposed to a first magnetic field for a first dwell period, thereby isolating the solid supports within the receptacle, where no portion of the fluid medium is removed from the receptacle at the first location. The receptacle is then transported from the first location to a second location of the system, where the fluid medium is exposed to a second magnetic field for a second dwell period. Following the second dwell period, at least a portion of the fluid medium is removed from the receptacle. A suspension fluid is then dispensed into the receptacle, and the contents of the receptacle are agitated to suspend the solid supports within the suspension fluid.