Double sided flow cell and other substrate imaging systems, such as imaging systems used in nucleic acid sequencing and similar processes. In one example, the imaging system includes a flipper to facilitate imaging different surfaces of the flow cell or other substrate. In another example, the imaging system includes two optical systems for imaging different surfaces of the flow cell or other substrate. In another example, the imaging system is an immersion system. In these and other examples, the system may include an auto-focus sub-system configured to accurately focus the optics on one surface of the double sided flow cell without interference from the other surface of the flow cell.

Disclosed are dielectric cavity arrays with cavities formed by pairs of dielectric tips, wherein the cavities have low mode volume (e.g., 7*10.sup.−5λ.sup.3, where X is the resonance wavelength of the cavity array), and large quality factor Q (e.g., 10.sup.6 or more). Applications for such dielectric cavity arrays include, but are not limited to, Raman spectroscopy, second harmonic generation, optical signal detection, microwave-to-optical transduction, and as light emitting devices.

A cuvette for analysis of liquids, including a first cuvette portion and a second cuvette portion, which are joined together, with a cuvette cavity, an inlet passage and an outlet passage being formed between the first cuvette portion and the second cuvette portion, the inlet passage and the outlet passage both in communication with the cuvette cavity, wherein the outlet passage is provided therein with a labyrinth-like sealing structure, which prevents backfill of a gas that has been discharged from the outlet passage during filling of a liquid to be analyzed in the cuvette.

A method for determining an optical pathlength through a cuvette of a spectrophotometric apparatus includes obtaining a first single beam spectrum of a liquid zero-material at least in a first energy region in which the liquid zero-material absorbs at least a portion of incident optical radiation; obtaining a second single beam spectrum of a second liquid at least in the first energy region, the second liquid having a composition excluding the liquid zero-material and having no absorption of incident optical radiation in the first energy region; determining a dual beam spectrum of the liquid zero-material relative to the second liquid at least in the first energy region from the first and second single beam spectra; and calculating an optical pathlength through the cuvette based on processing spectral information obtained from the first energy region of the determined dual beam spectrum.

Disclosed is a measurement apparatus including: a support mechanism configured to support a cartridge in which a chamber is formed, the chamber being configured to store a measurement sample that generates light an intensity of which varies depending on an amount of a test substance; a photodetector configured to detect the light generated from the measurement sample stored in the chamber; and a reflection member provided between the photodetector and the cartridge supported by the support mechanism, the reflection member having an inner face, the reflection member being configured to reflect, at the inner face, the light generated from the measurement sample stored in the chamber, and guide the light to the photodetector, wherein the reflection member is configured to have an area surrounded by the inner face, the area decreasing from a side where the cartridge supported by the support mechanism is provided toward a side where the photodetector is provided.

The present invention relates to a measurement device including a trace sample-use high sensitivity light absorbing cell, the device comprising: a light absorbing cell containing a capillary tube of which both ends are open hollow shaped; a light absorbing cell mounting block on which one end of the light absorbing cell is mounted, and which comprises a light emitting unit, disposed on the upper portion of the light absorbing cell, for irradiating light to one end of the light absorbing cell; and a light receiving block which comprises a light metering immersion unit disposed in such a manner that the other end of the light absorbing cell is immersed in a sample contained therein, and which detects light that is irradiated to one end of the light absorbing cell and emitted to the other end thereof.

The invention relates to an apparatus for the inline trace analysis of a liquid, preferably of an aqueous process solution, comprising: a housing (1); a micro-channel (2) through which the liquid to be examined is allowed to flow and into which light of a light source (3) is coupled; a detector (4) for light emerging from the micro-channel (2); and a user interface (5) for monitoring and/or operating the apparatus. The micro-channel (2), the detector (4) and/or the user interface (5) are arranged in the housing (1) and/or are integrated into the housing (1), and the housing (1) has a connection (6) for feeding the liquid in the micro-channel (2) and a connection (7) for power supply of the apparatus.

The present disclosure relates to a lid for a microtiter plate, which has a plurality of cavities arranged on a top of the microtiter plate and serve for receiving samples, wherein the lid is securable on the microtiter plate such that it covers of the microtiter plate. The lid has a basic body, which is embodied such that at least in regions, which are located above the cavities when the lid is on the microtiter plate, it is transmissive for light of predeterminable wavelength, and wherein the lid includes at least one closure element, which is embodied and/or arranged in such a manner that it closes at least one of the cavities in the microtiter plate when the lid is on the microtiter plate.

The present invention relates to a device (10) for use in fluid sample analysis. It is described to position (310) a top part (20) of the device (10) adjacent to a base part (30) of the device so as to define a fluidic receiving region in between, the top part being provided with a through opening fluidly connected to the fluidic receiving region, and the bottom part being provided with a radiation window adjacent to the fluidic receiving region. A fluidic sample is supplied (320) through the opening (24). The fluidic sample is moved laterally (330) in the fluid receiving region without the use of an intermediary membrane between the top part and the base part. A radiation is emitted (340) to the fluid receiving region. A radiation is detected (350) that is reflected by the device. A presence of the fluidic sample is determined (360) on the basis of a measured reflectance value based on the detected radiation.

A method for detecting the quality of cell culture fluid based on Raman spectral measurement. The method comprises the following steps: collecting cell culture fluid; collecting, processing and analyzing a Raman spectral signal; measuring an original Raman spectral signal of a metabolite in the cell culture fluid using a Raman spectra technique; determining whether the original Raman spectral signal is qualified, and carrying out data signal processing on the qualified original Raman spectral signal to obtain analyzable signals; and then carrying out difference statistical analysis on the analyzable signals to obtain difference signals; carrying out modeling using the difference signals; classifying the difference signals using a support vector machine; and distinguishing the spectral signals of normal and abnormal cell culture fluid to obtain a quality result of the cell culture fluid. Difference signals in cell culture fluid are detected by means of Raman spectra to detect the quality of the cell culture fluid, thereby achieving the purpose of non-invasive evaluation of a cell growth state; and the method is convenient, effective and low-cost, and can achieve large-scale industrialization and streamlining.