Patent classifications
G01N2201/1242
Methods and systems for nucleic acid sequencing validation, calibration and normalization
A system for performing quality control for nucleic acid sample sequencing is disclosed. The system comprises a set of solid supports, each solid support having attached thereto a plurality of nucleic acid sequences, wherein the set comprises plural groups of solid supports and each group contains solid supports having the same nucleic acid sequences attached thereto. The nucleic acid sequences of each group differ from each other. The nucleic acid sequences are synthetically derived, and the nucleic acids sequences are designed such that the nucleic acid sequences produce a predefined pattern of detectable signals during a sequencing run. A method of preparing a quality control for performing nucleic acid sample sequencing, a method of validating a nucleic acid sequencing instrument during a nucleic acid sequencing experiment, and a method of processing nucleic acid sequencing data during a nucleic acid sequencing experiment are also disclosed.
AUTOMATIC ANALYSIS DEVICE AND AUTOMATIC ANALYSIS METHOD
An automatic analysis device has a plurality of types of photometers having different quantitative ranges, and an analysis control unit for quantifying the desired component in specimens based on measurement values of one or more photometers selected from among the plurality of types of photometers. The analysis control unit: sets a switching region in an overlap region of respective quantitative ranges of the plurality of types of photometers, said switching region having a greater width than does the variation in quantitative values of the desired component based on the measurement values of photometers having the same specimen; compares the quantitative value of a quantitative range portion that corresponds to the switching region and the quantitative values of the desired component based on the measurement values of the photometers; and selects a photometer to be used in quantitative output of the desired component from among the plurality of types of photometers.
AUTOMATIC ANALYSIS DEVICE AND AUTOMATIC ANALYSIS METHOD
An automatic analysis device has a plurality of types of photometers having different quantitative ranges, and an analysis control unit for quantifying the desired component in specimens based on measurement values of one or more photometers selected from among the plurality of types of photometers. The analysis control unit: sets a switching region in an overlap region of respective quantitative ranges of the plurality of types of photometers, said switching region having a greater width than does the variation in quantitative values of the desired component based on the measurement values of photometers having the same specimen; compares the quantitative value of a quantitative range portion that corresponds to the switching region and the quantitative values of the desired component based on the measurement values of the photometers; and selects a photometer to be used in quantitative output of the desired component from among the plurality of types of photometers.
AUTOMATIC ANALYSIS DEVICE, AUTOMATIC ANALYSIS SYSTEM, AND AUTOMATIC ANALYSIS METHOD
The automatic analysis device is provided with (1) a measurement mechanism having a light measuring unit having a reaction container in which the sample is dispensed, a light source which emits light to the reaction container, and a detection unit that detects scattered light from the sample in the reaction container, (2) an amplifier circuit unit having an adder-subtractor that adds or subtracts a correction signal to or from a first measurement signal from the detection unit, and an amplifier circuit which amplifies the output signal by the adder-subtractor at a fixed amplification rate to output a second measurement signal, and (3) an arithmetic operation unit which calculates the correction signal on the basis of a difference between the signal level of the second measurement signal and a target value, and which executes an analysis action based on the second measurement signal after correction by means of the correction signal.
Automatic analyzer
According to one embodiment, an automatic analyzer includes a magnetic field generator, a photometric unit, a measurement unit, and a decision unit. The magnetic field generator causes magnetic separation in a reaction liquid stored in a cuvette by magnetic particles. The photometric unit includes a light source unit configured to generate light, and a detection unit configured to detect the light generated by the light source unit and generate an output signal corresponding to the detected light. The measurement unit measures a measurement item based on the output signal. The decision unit decides the use range of the output signal to be used to measure the measurement item in accordance with spatial unevenness of the magnetic separation by the magnetic field generator.
Measuring device and measuring method
A measuring device (10) and a measurement method measure a concentration of gaseous/aerosol components of a gas mixture. A reaction carrier (14) has a flow channel (42) defining a reaction chamber (46) having a optically detectable reaction material (48), that reacts with a gas mixture component or with a reaction product. The measuring device (12) includes a gas-conveying assembly (2) with a gas-conveying apparatus (28) conveying the gas mixture and a detection assembly (3), which has a lighting apparatus (37) for lighting the reaction chamber (46), an optical sensor (38) for sensing the optically detectable reaction, and an evaluating unit (4) evaluating sensor data and determining a concentration of the component of the gas mixture. The detection assembly (3) senses a speed of a reaction front (6) propagating in the flow direction in the reaction chamber (46) and determines a preliminary concentration from the speed of the reaction front (6).
Automatic analysis device and automatic analysis method
An automatic analysis device has a plurality of types of photometers having different quantitative ranges, and an analysis control unit for quantifying the desired component in specimens based on measurement values of one or more photometers selected from among the plurality of types of photometers. The analysis control unit: sets a switching region in an overlap region of respective quantitative ranges of the plurality of types of photometers, said switching region having a greater width than does the variation in quantitative values of the desired component based on the measurement values of photometers having the same specimen; compares the quantitative value of a quantitative range portion that corresponds to the switching region and the quantitative values of the desired component based on the measurement values of the photometers; and selects a photometer to be used in quantitative output of the desired component from among the plurality of types of photometers.
Onboard device and method for analyzing fluid in a heat engine
A method for controlling a spectrometer for analyzing a product includes steps of: acquiring a measurement representative of the operation of a light source, determining, depending on the measurement, a value of supply current of the light source, and/or a value of integration time of light-sensitive cells of a sensor, disposed on a route of a light beam emitted by the light source and having interacted with a product to be analyzed, and if the integration time and/or supply current value is between threshold values, supplying the light source with a supply current corresponding to the determined supply current value, adjusting the integration time of a light-sensitive cell to the determined integration time value, and acquiring light intensity measurements supplied by the sensor, enabling a spectrum to be formed.
Onboard device and method for analyzing fluid in a heat engine
The present invention relates to a method for controlling a spectrometer for analyzing a product, the spectrometer including a light source including several light-emitting diodes having respective emission spectra covering in combination an analysis wavelength band, the method including steps of: supplying at least one of the light-emitting diodes with a supply current to switch it on, measuring a light intensity emitted by the light source by measuring a current at a terminal of at least another of the light-emitting diodes maintained off, determining, according to each light intensity measurement, a setpoint value of the supply current of each diode that is on, and regulating the supply current of each diode that is on so that it corresponds to the setpoint value.
MEASUREMENT SYSTEM AND MEASUREMENT METHOD
A measurement system comprises a light source configured to irradiate excitation light to a fluorescent substance kept in a sample container, the sample container containing a sample comprising the fluorescent substance, a detector configured to detect radiated light emitted from the fluorescent substance depending on the excitation light, a measurement device configured to measure a concentration of the fluorescent substance based on a detection signal detected by the detector, and a washing device configured to supply washing liquid for washing the sample container to the sample container, and the measurement device comprises a first determination unit configured to execute a first determination process. A first measurement unit is configured to execute an analog measurement and a second measurement unit is configured to execute a digital measurement.