A Heisenberg scaler reduces noise in quantum metrology and includes: a stimulus source that provides physical stimuli; a physical system including quantum sensors that receive a first and second physical stimuli; produces a measured action parameter; receives an perturbation pulse; and produces modal amplitude; an estimation machine that: receives the measured action parameter and produces a zeroth-order value from the measured action parameter; a gradient analyzer that: receives the measured action parameter and produces the measured action parameter and a gradient; the sensor interrogation unit that: receives the modal amplitude; receives the gradient and the measured action parameter; produces the perturbation pulse; and produces a first-order value from the modal amplitude, the gradient, and the measured action parameter; a Heisenberg determination machine that: receives the zeroth-order value; receives the first-order value; and produces a physical scalar from the zeroth-order value and the first-order value.

A method of authenticating an article, the method comprising: reading a label associated with the article, the label comprising article fingerprint information; retrieving, in dependence on the article fingerprint information, an article fingerprint, the fingerprint describing the resonance response of the article to an excitation signal; applying an excitation signal to the article; receiving the resonance response of the article to the excitation signal; comparing the resonance response to the fingerprint; and determining in dependence on the comparison whether the article is authentic.

Molecular rotational resonance (MRR) spectroscopy is a structurally-specific, high-resolution spectroscopy technique that can provide accurate reaction process data with finer time resolution than existing techniques. It is the only analytical technique that can make online chiral composition measurements. This makes it especially useful for online reaction monitoring, which is done today by manually pulling off samples and measuring samples offline and takes 3-4 hours per measurement. Conversely, an MRR spectrometer can resolve isomers in about 10 minutes when fed with a low-volatility sampling interface that connects directly to the reaction line. The sampling interface measures a precise sample of the reaction solution, boils off the solvent to concentrate the analyte, volatilizes the analyte, and injects the volatilized analyte into the MRR spectrometer's measurement chamber for an MRR measurement. The sample concentration and volatilization happen quickly and without any extra sample preparation.

A method of authenticating an article, the method comprising: reading a label associated with the article, the label comprising article fingerprint information; retrieving, in dependence on the article fingerprint information, an article fingerprint, the fingerprint describing the resonance response of the article to an excitation signal; applying an excitation signal to the article; receiving the resonance response of the article to the excitation signal; comparing the resonance response to the fingerprint; and determining in dependence on the comparison whether the article is authentic.

An exhaust gas sensing system includes a channel for flow of exhaust gas, a first directional antenna, a second directional antenna, a first transmitter, a first receiver, and signal processing circuitry. The first directional antenna and the second directional antenna are disposed in the channel. The first transmitter is coupled to the first directional antenna. The first receiver is coupled to the second directional antenna. The signal processing circuitry is coupled to the first transmitter and the first receiver.

A Heisenberg scaler reduces noise in quantum metrology and includes: a stimulus source that provides physical stimuli; a physical system including quantum sensors that receive a first and second physical stimuli; produces a measured action parameter; receives an perturbation pulse; and produces modal amplitude; an estimation machine that: receives the measured action parameter and produces a zeroth-order value from the measured action parameter; a gradient analyzer that: receives the measured action parameter and produces the measured action parameter and a gradient; the sensor interrogation unit that; receives the modal amplitude; receives the gradient and the measured action parameter produces the perturbation pulse; and produces a first-order value from the modal amplitude, the gradient, and the measured action parameter; a Heisenberg determination machine that: receives the zeroth-order value; receives the first-order value; and produces a physical scalar from the zeroth-order value and the first-order value.

Disclosed herein are methods of preparing a composition comprising crystalline biomolecules, for example, crystalline antibodies. In exemplary embodiments, the method comprises forming a fluidized bed of crystalline biomolecules using, for example, a counter-flow centrifuge to exchange buffer and/or to concentrate the crystalline biomolecules in a solution. Also provided are methods of detecting crystalline biomolecules and/or amorphous biomolecules in a sample.

Nuclear Magnetic Resonant Imaging (also called Magnetic Resonant Imaging or MRI) devices which are implantable, internal or insertable are provided. The disclosure describes ways to miniaturize, simplify, calibrate, cool, and increase the utility of MRI systems for structural investigative purposes, and for biological investigation and potential treatment. It teaches use of target objects of fixed size, shape and position for calibration and comparison to obtain accurate images. It further teaches cooling of objects under test by electrically conductive leads or electrically isolated leads; varying the magnetic field of the probe to move chemicals or ferrous metallic objects within the subject. The invention also teaches comparison of objects using review of the frequency components of a received signal rather than by a pictorial representation.

Nuclear Magnetic Resonant Imaging (also called Magnetic Resonant Imaging or MRI) devices which are implantable, internal or insertable are provided. The disclosure describes ways to miniaturize, simplify, calibrate, cool, and increase the utility of MRI systems for structural investigative purposes, and for biological investigation and potential treatment. It teaches use of target objects of fixed size, shape and position for calibration and comparison to obtain accurate images. It further teaches cooling of objects under test by electrically conductive leads or electrically isolated leads; varying the magnetic field of the probe to move chemicals or ferrous metallic objects within the subject. The invention also teaches comparison of objects using review of the frequency components of a received signal rather than by a pictorial representation.

Disclosed herein are methods of preparing a composition comprising crystalline biomolecules, for example, crystalline antibodies. In exemplary embodiments, the method comprises forming a fluidized bed of crystalline biomolecules using, for example, a counter-flow centrifuge to exchange buffer and/or to concentrate the crystalline biomolecules in a solution. Also provided are methods of detecting crystalline biomolecules and/or amorphous biomolecules in a sample.