An NMR spectrum is acquired from a nucleus of interest in a solvent included in a sample solution. A spectrum analyzer analyzes a number of splits, a splitting interval, a number of signals, and a signal interval based on the NMR spectrum. Based on these characteristic quantities, an identifier identifies the solvent. In another configuration, a plurality of NMR spectra acquired from a plurality of nuclei of interest included in the solvent may be analyzed.

An experimental technology for detecting a hydrogen bond based on an ssNMR technology includes: (1) exciting a .sup.1H nucleus of an RNA sample with a π/2 pulse; (2) applying two π pulses every half rotation period on an X_nucleus of the RNA sample; (3) applying a π pulse on the .sup.1H nucleus of the RNA sample; (4) applying two π pulses every half rotation period on the X nucleus of the RNA sample; (5) applying a 90° pulse on .sup.1H and X atoms of the RNA sample; (6) recording a chemical shift of X in indirect dimension; (7) applying the 90° pulse on the .sup.1H and X nuclei of the RNA sample; (8) repeating steps 2, 3, and 4; and (9) collecting the .sup.1H signal in direct dimension; where X is selected from the group consisting of .sup.15N and .sup.13C.

Embodiments of the present disclosure provide an interrogation device that is operable to apply one or more source signals to one or more coils surrounding a volume, where a material is disposed within the volume. Each of the one or more source signals may excite one of the one or more coils, and the behavior of each the one or more coils responsive to the exciting may be monitored. One or more parameters may be determined based on the behavior of each the one or more coils, and the one or more parameters may be utilized to generate a signature for the material within the volume. The signature may be compared to one or more signatures of known materials to identify the material within the volume.

The present invention generally pertains to methods of characterizing antibody higher order structure. In particular, the present invention pertains to the use of novel NMR methods to compare manufacturing process variability in antibody higher order structure.

A method for determination of molecular parameters for a configuration of a known single organic molecule embedded in an anisotropic environment generated by alignment media, said known single organic molecule comprising particles, is disclosed. The method comprising the steps of: a) Defining a three-dimensional grid that is aligned with the known atomic structure of the alignment medium; b) Placing the particles of the known single organic molecule on the respective grid points of the three-dimensional grid in relation to at least one assigned atom of the alignment medium; c) Determining the interaction between the particles of the single organic molecule and the alignment medium for a set of orientations and a plurality of configurations of the particles; d) Calculating anisotropic parameters obtainable by measuring with nuclear magnetic resonance (NMR) spectroscopy by use of the determined interactions for each of the plurality of configurations of the organic molecule.

Provided is a method for analyzing the content of D-lactic repeating units (D content) in polylactic acid that has a feature that the D content in polylactic acid can be quickly and accurately analyzed by using NMR data of polylactic acid and hypothetical polylactic acid without special chemical treatment for polylactic acid.

The present invention relates to a system and method for carbohydrate analysis in a flow chemistry manner. The present invention at least features continuous reactions of glycan hydrolysis in combination with saccharide labeling which is helpful to improve the existing approaches in glycan structural analysis.

The present invention relates to a method for analyzing the length of sulfur crosslinking bonds in a vulcanized rubber using NMR spectrum.

Provided is a method for quantitating a saccharide in a liquid sample. The method comprises incubating the liquid sample with 2,3-naphthalenediamine in the presence of iodine to allow a naphthimidazole group to be linked to the saccharide to obtain a first mixture; obtaining an .sup.1H-NMR spectrum of the first mixture; and comparing, in said .sup.1H-NMR spectrum, the intensity or integral of a proton signal corresponding to the saccharide to the intensity or integral of a proton signal corresponding to an internal standard present in the first mixture.

An exemplary integrated nuclear quadrupole resonance-based detection system comprises a front-end device having a hand-held form factor, wherein the front-end device is configured to scan a sample in or near a sample coil using inbuild electronics and acquire a nuclear quadrupole resonance measurement. The system further includes a swappable sample coil that is attached to an opening at a face of the front-end device and is tuned to a resonant frequency of the sample; and a swappable impedance matching network that is attached to the opening at the face of the front-end device and is configured to tune the resonant frequency of the sample coil. The inbuild electronics comprises a wireless transfer module that is configured to communicate the acquired nuclear quadrupole resonance measurement with a back-end device of the integrated nuclear quadrupole resonance-based detection system. Other systems and methods are also provided.