An example biosensor includes a substrate, a graphene layer disposed on the substrate, and a binding site bonded to the graphene. The binding site includes an antibody configured to bind a SARS-CoV-2 spike glycoprotein.

Concrete can be one of the most durable building materials and structures made of concrete can have a long service life. Consumption is projected to reach approximately 40 billion tons in 2017. Despite this the testing of concrete at all stages of its life cycle is still in its early stages although testing for corrosion is well established. Further many of the tests today are time consuming, expensive, and provide results only after it has been poured and set. Embodiments of the invention provide concrete suppliers, construction companies, regulators, architects, and others with rapid testing and performance data regarding the cure, performance, corrosion of concrete at different points in its life cycle based upon a simple electrical tests that remove subjectivity, allow for rapid assessment, are integrable to the construction process, and provided full life cycle assessment. Wireless sensors can be embedded from initial loading through post-cure into service life.

The embodiments provide a method making it possible to safely and inexpensively measure concentrations of combustible gases, such as methanol, at room temperature even in high concentration atmospheres, and also provide a sensor making it possible to carry out the above measurement method. The measurement method comprises: arranging a film containing nanoparticles of tungsten oxide and a pair of electrodes which are separated from each other and which individually keep in contact with said film in said atmosphere, exposing said film to light, measuring electric resistance change of said film before and after exposing said film to light, and determining said concentration based on said change.

Embodiments herein include a kinetic response system for measuring analyte presence on a chemical sensor element. The chemical sensor element includes one or more discrete binding detectors, each discrete binding detector including a graphene varactor. The kinetic response system includes a measurement circuit having an excitation voltage generator for generating a series of excitation cycles over a time period. Each excitation cycle includes delivering a DC bias voltage to the discrete binding detectors at multiple discrete DC bias voltages across a range of DC bias voltages. The kinetic response system includes a capacitance sensor to measure capacitance of the discrete binding detectors resulting from the excitation cycles. The kinetic response system includes a controller circuit to determine the kinetics of change in at least one of a measured capacitance value and a calculated value based on the measured capacitance over the time period. Other embodiments are also included herein.

A method of identifying a potential therapeutic compound that affects a Receptor Tyrosine Kinase (RTK) pathway in cancer cells, which includes: providing a device capable of measuring cell-substrate impedance; culturing cancer cells in serum-free media in at least two wells of the device; adding to a first well a proposed therapeutic compound that affects a RTK pathway and a RTK stimulating factor for the RTK pathway to form a test well, and adding to another well the RTK stimulating factor to form a control well; continuously monitoring cell-substrate impedance of the at least two wells and optionally determining cell indices from the monitored cell-substrate impedance; and determining a difference in impedance or optionally cell index between the test well and control well; and if significantly different, concluding the proposed therapeutic compound is therapeutically active in the RTK pathway within the cancer cells.

A method for detection and monitoring a therapeutic effect of a cancer treatment drug is disclosed. The method includes steps of removing a malignant biological cell lines from a tumor; culturing the removed biological cell lines in a controlled set of conditions; seeding the cultured biological cell lines on silicon nanowire electrode arrays of an electrical cell-substrate impedance sensor (ECIS); adding a cancer treatment drug to the seeded biological cell lines to treat the seeded biological cell lines; and measuring an electrical impedance of the treated biological cell lines for detection and monitoring a therapeutic effect of the cancer treatment drug.

Described systems and methods allow the detection and quantitation of a target analyte such as a toxin, drug, pesticide, etc. Some embodiments use a sensor comprising photo-sensitive cells, e.g., cells genetically modified to express an opsin. A light source such as an LED is used to optically stimulate the sensor cells, triggering changes in a measurable quantity such as the polarization of the cell membrane. Some embodiments use electrical impedance measurements to monitor the cell's recovery from the state induced by the optical stimulation. The recovery process is affected by the presence of certain bio-active compounds, which allows detection and quantitation of such compounds.

Concrete can be one of the most durable building materials and structures made of concrete can have a long service life. Consumption is projected to reach approximately 40 billion tons in 2017. Despite this the testing of concrete at all stages of its life cycle is still in its early stages although testing for corrosion is well established. Further many of the tests today are time consuming, expensive, and provide results only after it has been poured and set. Embodiments of the invention provide concrete suppliers, construction companies, regulators, architects, and others with rapid testing and performance data regarding the cure, performance, corrosion of concrete at different points in its life cycle based upon a simple electrical tests that remove subjectivity, allow for rapid assessment, are integrable to the construction process, and provided full life cycle assessment. Wireless sensors can be embedded from initial loading through post-cure into service life.

A wireless chemical sensor includes an electrical conductor and a material separated therefrom by an electric insulator. The electrical conductor is an unconnected open-circuit shaped for storage of an electric field and a magnetic field. In the presence of a time-varying magnetic field, the first electrical conductor resonates to generate harmonic electric and magnetic field responses. The material is positioned at a location lying within at least one of the electric and magnetic field responses so-generated. The material changes in electrical conductivity in the presence of a chemical-of-interest.

A high temperature corrosion sensor is provided having (i) a housing having an external wall and an internal wall, the internal wall of the housing forming a chamber of the housing, (ii) a stainless steel tube inserted into the chamber, (iii) a ceramic tube wherein at least a portion of the ceramic tube is inserted into the stainless steel tube, (iv) an airflow tube that extends through the chamber, and (v) a sensor probe having a first working electrode, a second working electrode, a reference electrode, a positive electrical resistance, a negative electrical resistance, and a thermocouple, wherein at least a portion of each are encapsulated into a ceramic casting that is located at one end of the housing. Methods of measuring corrosion within a power plant environment are provided.