A sampling unit includes a needle for aspirating a sample fluid, a housing, and a fitting. The needle includes a needle tip and a needle channel through the needle for guiding the aspirated sample fluid. The needle channel opens at the needle tip. The housing includes a housing cavity and a housing channel opening into the housing cavity. The fitting includes a fitting cavity and a fitting channel. The fitting is configured for sealingly receiving the needle tip into the fitting cavity and for being inserted into the housing cavity, so that the fitting channel on one side fluidically couples to the needle channel and on another side couples to the housing channel.

An autosampler sets an injection valve to be in a sample filling state when a sample loop is filled with a sample, and, after completion of filling with the sample, switches the injection valve to an intermediate state and first connects only one end of the sample loop to a liquid delivery channel and an analysis channel. After the above, the injection valve is switched to the sample injection state and the sample loop is interposed between the liquid delivery channel and the analysis channel, so that the sample is injected into the analysis channel.

A sampling needle (2) having a suction port at a tip, a movement mechanism (4) that moves the needle (2) at least in a vertical direction while holding the needle (2) in a state where the suction port faces vertically downward, a suction mechanism (6) for sucking liquid through the needle (2), a controller (10) configured to control operation of the movement mechanism (4) and the suction mechanism (6) are included. In sampling of liquid from a container (16) whose upper surface is opened, the controller (10) is configured to execute an inserting step of inserting the tip of the needle (2) into the liquid in the container (16) by lowering the needle (2) from above the container (16), a sucking step of sucking a predetermined amount of the liquid from the suction port of the needle (2) after the inserting step is completed, a pulling up step of pulling up the needle (2) from the liquid to position the suction port above a liquid level of the liquid after the sucking step is completed, and a shaking-off step of repeating shaking-off operation of lowering and suddenly stopping the needle (2) a plurality of times with standby time in which the needle (2) is completely stopped or raised in between while maintaining a state where the suction port is positioned above the liquid level after the pulling up step is completed.

A sampling needle (2) having a suction port at a tip, a movement mechanism (4) that moves the needle (2) at least in a vertical direction while holding the needle (2) in a state where the suction port faces vertically downward, a suction mechanism (6) for sucking liquid through the needle (2), a controller (10) configured to control operation of the movement mechanism (4) and the suction mechanism (6) are included. In sampling of liquid from a container (16) whose upper surface is opened, the controller (10) is configured to execute an inserting step of inserting the tip of the needle (2) into the liquid in the container (16) by lowering the needle (2) from above the container (16), a sucking step of sucking a predetermined amount of the liquid from the suction port of the needle (2) after the inserting step is completed, a pulling up step of pulling up the needle (2) from the liquid to position the suction port above a liquid level of the liquid after the sucking step is completed, and a shaking-off step of repeating shaking-off operation of lowering and suddenly stopping the needle (2) a plurality of times with standby time in which the needle (2) is completely stopped or raised in between while maintaining a state where the suction port is positioned above the liquid level after the pulling up step is completed.

A method for scientific instrument support includes obtaining a chromatographic data. The method includes one of (a) calculating an intensity score for the chromatographic data and identifying an injection miss when the intensity score is below a score threshold or (b) applying a machine learning model to classify the chromatographic data. The method further includes notifying a user of an injection miss or injection error.

An autosampler is switched selectively between an injecting mode where a sampling flow path is incorporated into an analysis flow path of a liquid chromatograph and a loading mode where the sampling flow path is not incorporated into the analysis flow path and injects a sample into the analysis flow path at a position farther upstream than a separation column by being switched to the injecting mode with the sample held in the sampling flow path, and includes a clog determiner configured to acquire a sending liquid pressure of a liquid sending pump that sends a mobile phase in the analysis flow path, obtain a variation value of the liquid sending pressure when the injecting mode and the loading mode are switched and determine presence or absence of a clog in a system incorporated into the analysis flow path in the injecting mode based on the obtained variation value.

An autosampler is switched selectively between an injecting mode where a sampling flow path is incorporated into an analysis flow path of a liquid chromatograph and a loading mode where the sampling flow path is not incorporated into the analysis flow path and injects a sample into the analysis flow path at a position farther upstream than a separation column by being switched to the injecting mode with the sample held in the sampling flow path, and includes a clog determiner configured to acquire a sending liquid pressure of a liquid sending pump that sends a mobile phase in the analysis flow path, obtain a variation value of the liquid sending pressure when the injecting mode and the loading mode are switched and determine presence or absence of a clog in a system incorporated into the analysis flow path in the injecting mode based on the obtained variation value.

The present invention addresses to an automated gas injection system in vials with rubber septa, for simultaneous injection of gas in 24 or more positions, with injection pressure control and/or overpressure detection, applied to mass spectrometry analyses and/or gas chromatography. The present invention can be used, for example, in isotopic analyses of geological materials in equipment with carbonate extraction units, in the cleaning and decontamination of tubes to be used in isotopic or chromatographic analyses, and in the removal of contaminants from steam drag or by continuous flow, or coming from the free space of vials or tubes in the analyses of organic and inorganic materials.

The application of this invention allows reducing the current times of routine purge (flush) of at very least 3 minutes for every 2 positions (72 positions in total and final time of 108 minutes, in a batch of samples) to a total of 96 positions in 3 minutes, with a reduction of 12 times or more in the flush time, which implies greater analytical capacity to the laboratory, lower external costs of sending samples, less time to obtain results, with technology that is easy to implement in universities and research centers in general, in addition to increasing the lifespan of rubber septa.

The present invention addresses to an automated gas injection system in vials with rubber septa, for simultaneous injection of gas in 24 or more positions, with injection pressure control and/or overpressure detection, applied to mass spectrometry analyses and/or gas chromatography. The present invention can be used, for example, in isotopic analyses of geological materials in equipment with carbonate extraction units, in the cleaning and decontamination of tubes to be used in isotopic or chromatographic analyses, and in the removal of contaminants from steam drag or by continuous flow, or coming from the free space of vials or tubes in the analyses of organic and inorganic materials.

The application of this invention allows reducing the current times of routine purge (flush) of at very least 3 minutes for every 2 positions (72 positions in total and final time of 108 minutes, in a batch of samples) to a total of 96 positions in 3 minutes, with a reduction of 12 times or more in the flush time, which implies greater analytical capacity to the laboratory, lower external costs of sending samples, less time to obtain results, with technology that is easy to implement in universities and research centers in general, in addition to increasing the lifespan of rubber septa.

Described herein are devices and methods of use thereof, the devices comprising: a sample conduit providing a path for fluid flow extending from a sample inlet to a sample outlet; a thermal housing enclosing the sample conduit, the thermal housing comprising a plurality of measurement regions; and a motorized stage translatable along the thermal housing so as to align a detector with one or more of the plurality of measurement regions. The devices can continuously flow a fluid precursor sample from the sample inlet to the sample outlet, the fluid precursor sample comprising a first precursor and a second precursor, such that the first precursor reacts with the second precursor as the fluid precursor sample continuously flows from the sample inlet to the sample outlet to form the sample before reaching the sample outlet, wherein the sample comprises a plurality of particles or an organic molecule.