A gas chromatograph is provided with: a sample gas generator (2) configured to generate a sample gas from an injected sample; a separation column (6) fluidly connected to an outlet of the sample gas generator, the separation column (6) being configured to separate components in the sample gas generated by the sample gas generator (2); a detector (8) fluidly connected to an outlet of the separation column (6), the detector (8) being configured to detect the components separated in the separation column (6); a plurality of gas supply sources (12A, 12B) each configured to supply a carrier gas for carrying the sample gas generated by the sample gas generator to the separation column (6); a switching unit (12A, 12B) fluidly connected to the plurality of gas supply sources, the switching unit being configured to switch such that one of the plurality of gas supply sources is fluidly connected to the sample gas generator (2); a regulator (16) interposed between the switching unit (14) and the sample gas generator (2), the regulator (16) being configured to regulate a gas supply pressure from the gas supply source (12A, 12B) and a gas supply flow rate to the sample gas generator (2); and a control unit (30) configured to control an operation of the regulator (16), wherein the control unit (30) is configured such that in a case where the gas supply source fluidly connected to the sample gas generation unit has been changed in order to shift to a standby state capable of performing subsequent sample analysis and that at least a gas type of the carrier gas supplied to the supply gas generation unit (2) has been changed, the control unit (30) performs a replacement promotion operation for putting the gas supply pressure, the gas supply flow rate, or a combination thereof to a state different from the standby state to promote a gas replacement in the flow path for the carrier gas.

A gas chromatograph is provided with: a sample gas generator (2) configured to generate a sample gas from an injected sample; a separation column (6) fluidly connected to an outlet of the sample gas generator, the separation column (6) being configured to separate components in the sample gas generated by the sample gas generator (2); a detector (8) fluidly connected to an outlet of the separation column (6), the detector (8) being configured to detect the components separated in the separation column (6); a plurality of gas supply sources (12A, 12B) each configured to supply a carrier gas for carrying the sample gas generated by the sample gas generator to the separation column (6); a switching unit (12A, 12B) fluidly connected to the plurality of gas supply sources, the switching unit being configured to switch such that one of the plurality of gas supply sources is fluidly connected to the sample gas generator (2); a regulator (16) interposed between the switching unit (14) and the sample gas generator (2), the regulator (16) being configured to regulate a gas supply pressure from the gas supply source (12A, 12B) and a gas supply flow rate to the sample gas generator (2); and a control unit (30) configured to control an operation of the regulator (16), wherein the control unit (30) is configured such that in a case where the gas supply source fluidly connected to the sample gas generation unit has been changed in order to shift to a standby state capable of performing subsequent sample analysis and that at least a gas type of the carrier gas supplied to the supply gas generation unit (2) has been changed, the control unit (30) performs a replacement promotion operation for putting the gas supply pressure, the gas supply flow rate, or a combination thereof to a state different from the standby state to promote a gas replacement in the flow path for the carrier gas.

A mobile phase monitor includes a measurement unit, an arithmetic unit, a storage, and a discrimination unit. The measurement unit measures a weight of a mobile phase container. The arithmetic unit produces a calibration curve indicating a relationship between a measurement value of the measurement unit and a liquid amount of the mobile phase accommodated in the mobile phase container. The arithmetic unit calculates the liquid amount of the mobile phase from the measurement value of the measurement unit based on the produced calibration curve. The storage stores a plurality of calibration curves respectively corresponding to a plurality of types of mobile phases. The discrimination unit discriminates a type of the mobile phase accommodated in the mobile phase container by searching for the produced calibration curve from the plurality of calibration curves stored in the storage.

A mobile phase monitor includes a measurement unit, an arithmetic unit, a storage, and a discrimination unit. The measurement unit measures a weight of a mobile phase container. The arithmetic unit produces a calibration curve indicating a relationship between a measurement value of the measurement unit and a liquid amount of the mobile phase accommodated in the mobile phase container. The arithmetic unit calculates the liquid amount of the mobile phase from the measurement value of the measurement unit based on the produced calibration curve. The storage stores a plurality of calibration curves respectively corresponding to a plurality of types of mobile phases. The discrimination unit discriminates a type of the mobile phase accommodated in the mobile phase container by searching for the produced calibration curve from the plurality of calibration curves stored in the storage.

A method for anomaly detection and diagnosis in a chromatography system including a sample handling unit, a chromatographic separation unit, and a detection unit is disclosed. The method can include performing, with the chromatography system, a chromatography analysis of a sample to obtain a chromatogram of the sample, the sample including a known quantity of a reference standard. The method can also include determining peak information corresponding to the reference standard in the chromatogram and determining whether the peak information conforms with an expected response of the chromatography system associated with the reference standard. If the peak information does not conform with the expected response, the method can include determining that there is an anomaly in the operation of the chromatography system and diagnosing a cause of the anomaly as relating to the operation of at least one the sample handling unit, the chromatographic separation unit, and the detection unit.

A method for anomaly detection and diagnosis in a chromatography system including a sample handling unit, a chromatographic separation unit, and a detection unit is disclosed. The method can include performing, with the chromatography system, a chromatography analysis of a sample to obtain a chromatogram of the sample, the sample including a known quantity of a reference standard. The method can also include determining peak information corresponding to the reference standard in the chromatogram and determining whether the peak information conforms with an expected response of the chromatography system associated with the reference standard. If the peak information does not conform with the expected response, the method can include determining that there is an anomaly in the operation of the chromatography system and diagnosing a cause of the anomaly as relating to the operation of at least one the sample handling unit, the chromatographic separation unit, and the detection unit.

A gas chromatograph is provided with: a sample gas generator; a separation column; a detector; a plurality of gas supply sources; a switching unit; a regulator-; and an out-of-gas determination unit. After the out of gas determination unit has determined that the out of gas has occurred in the gas supply source supplying the carrier gas to the sample gas generator, it is configured to perform a column protection operation for changing the gas supply source fluidly connected to the sample gas generator by the switching unit.

A suppressor device for an ion chromatograph is provided between a separation column and a detector of an ion chromatograph. An electrodialysis suppressor includes a first flow path to which an eluent flowing from the separation column is supplied, a second flow path to which a regeneration liquid is supplied, an ion exchange membrane provided between the first flow path and the second flow path and an electrode to which a voltage is applied. A power supply circuit that applies a voltage to the electrode is turned off in a case in which an eluent is not supplied to the first flow path of the electrodialysis suppressor.

An analysis method includes: performing liquid chromatography using a mobile phase including an adsorption prevention agent for preventing adsorption of a sample including a compound having a phosphate group to metal; and performing mass spectrometry on an eluate of the liquid chromatography. The adsorption prevention agent includes an oxalic acid or a salt of the oxalic acid.

An object of the present invention is to provide a novel method for determining the structure of a target substance contained in a multicomponent sample. The present invention provides a method of determining the structure of a target substance contained in a mixture of two or more substances, wherein the method includes the steps of: isolating the target substance from the mixture by means of supercritical fluid chromatography, soaking the isolated target substance into a crystalline sponge to produce a sample for crystallography, and performing a crystallographic analysis on the sample for crystallography. A volatile solvent can be used as a mobile phase in the supercritical fluid chromatography.