Disclosed is an assay for determining resistance in a target cell or tissue to a therapy associated with cellular stress using chemical microscopy and high-throughput single cell analysis to determine functional metabolic alteration, including determining metabolic reprogramming in a target cell or tissue to a therapy associated with cellular stress, and methods of using the assays.

Systems and methods for assessing a microbial characteristic within a growing medium. Such a system assesses one or more microbial characteristics, such as biomass and/or microbial activity, within a growing medium, such as soil. Electrical properties of a microbially degradable material in contact with the growing medium are measured. The measurements are used to determine the microbial characteristic(s) based at least partly on degradation of the microbially degradable material.

A method of analysis using mass spectrometry and/or ion mobility spectrometry is disclosed comprising: (a) using a first device to generate smoke, aerosol or vapour from a target in vitro or ex vivo cell population; (b) mass analysing and/or ion mobility analysing said smoke, aerosol or vapour, or ions derived therefrom, in order to obtain spectrometric data; and (c) analysing said spectrometric data in order to identify and/or characterise said target cell population or one or more cells and/or compounds present in said target cell population.

To provide a potential measurement device capable of keeping a temperature of a cell and/or a culture solution (in particular, a temperature of a cell) constant. Provided is a potential measurement device including a semiconductor substrate; a wiring layer on the semiconductor substrate; a first electrode on the wiring layer; and a second electrode configured to detect an action potential of a cell on the wiring layer. A temperature measurement unit is formed on the semiconductor substrate. A heat conduction unit and a plurality of wirings connected to the second electrode are formed in the wiring layer.

A sensor device for use in sensing a change in a concentration of micro-organisms, comprises a waveguide interferometer having a sensing arm and a reference arm, a microfluidic channel for a fluid containing the micro-organisms, and a trapping arrangement in the microfluidic channel for physically trapping the micro-organisms when the fluid flows along the microfluidic channel so as to concentrate the micro-organisms in a sensing region of the microfluidic channel. The sensing arm is configured to guide sensing light, the reference arm is configured to guide reference light, and the waveguide interferometer is configured to interfere the sensing light with the reference light. The waveguide interferometer and the microfluidic channel are configured to allow the sensing light to interact with the fluid and the micro-organisms in the sensing region of the microfluidic channel.

A culture device is applicable to measurement of an electrical resistance of cells. The culture device includes a measurement chamber, a permeable layer, an upper working electrode, and a lower working electrode. The measurement chamber is longer in a first direction than in a second direction intersecting the first direction. The permeable layer partitions the measurement chamber into a first chamber on an upper side and a second chamber on a lower side. The permeable layer is permeable to liquid. The upper working electrode is disposed on the upper side with respect to the measurement chamber, and has working electrode portions longer in the first direction than in the second direction. The lower working electrode is disposed on the lower side with respect to the measurement chamber, and has working electrode portions longer in the first direction than in the second direction.

Novel Coronavirus/MERS-CoV/Influenza Virus A/B Multiple Rapid Detection Kit is disclosed. The kit has the advantages of high sensitivity, good specificity, high speed (3-15 minutes), simplicity and low cost.

Novel Coronavirus/MERS-CoV/Influenza Virus A/B Multiple Rapid Detection Kit is disclosed. The kit has the advantages of high sensitivity, good specificity, high speed (3-15 minutes), simplicity and low cost.

Disclosed is an assay for determining resistance in a target cell or tissue to a therapy associated with cellular stress using chemical microscopy and high-throughput single cell analysis to determine functional metabolic alteration, including determining metabolic reprogramming in a target cell or tissue to a therapy associated with cellular stress, and methods of using the assays.

The invention relates to a system for detecting at least one species present in a fluid, preferably for detecting at least one circulating cell or aggregate of cells present in a human or animal biological fluid, and in particular circulating tumour cells (CTC) present in a blood fluid, the detection system comprising means (20) for filtering the fluid, the filtering means (20) comprising a filtering membrane (21), the filtrating membrane comprising at least one pore (22) designed to retain a species of a given type present in the fluid, the filtration means (20) further comprising at least one opening (23) designed to ensure, during operation within the fluid, the continuous circulation of the biological fluid, even when the at least one pore (22) is occupied.