The disclosure relates to a liquid suction device and a sample analyzer, the liquid suction device is configured for sucking liquid in a containing box having a plurality of containing cavities, and the liquid suction device includes a supporting piece; and a plurality of liquid suction mechanisms, each of the liquid suction mechanisms includes a rotating unit, the rotating unit is slidably connected with the supporting piece and includes a rotating shaft, the central axis of the rotating shaft extends in the gravity direction, the liquid suction mechanism can revolve around the rotating shaft, and liquid in the different containing cavities in the containing box can be sucked by the plurality of liquid suction mechanisms at the same time.

Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

Aspects of the present disclosure relate to methods and devices for automatically transferring samples and/or reagents from sample vessels and/or reagent vessels into at least one receiving vessel In one example embodiment, a pipetting device is disclosed including a pipettor that is movable along a first direction and has at least one first pipetting needle that is movable along an arm of the pipettor along a second direction, substantially normal to the first direction. The pipetting needle is lowerable along a third direction into the individual vessels. In some specific embodiments, the arm of the movable pipettor has at least one second pipetting needle which, regardless of the current position of the first pipetting needle, is movable past the first pipetting needle and is lowerable into the individual vessels.

The present invention relates to a fluid transport system for an automated slide treatment apparatus for treating one or more tissue samples disposed on slides, whereby the slide treatment apparatus includes a plurality of slide treatment modules arranged to receive ones of the slides, and the fluid transport system includes a fluid dispensing robot configured by a controller to dispense a plurality of reagents to said ones of the slides received in the slide treatment modules to treat said one or more tissue samples respectively.

Various embodiments include a system having a pipetting chamber, a set of pipettor cartridges docked in the pipetting chamber, a gantry system mounted on a ceiling within the pipetting chamber, the gantry system including at least one stationary track aligned in a first direction, and a movable track aligned in a second direction distinct from the first direction, the movable track coupled to the at least one stationary track, and a carrier configured to transport each of the set of pipettor cartridges to a pipetting location within the pipetting chamber, the carrier configured to move each pipettor cartridge in a third direction perpendicular to both the first and second directions.

A liquid chromatography system includes a solvent delivery system, a sample manager including a sample delivery system in fluidic communication with the solvent delivery system, the sample delivery system configured to inject a sample from a sample-vial into a chromatographic flow stream, a liquid chromatography column located downstream from the sample delivery system, and a detector located downstream from the liquid chromatography column. The sample delivery system further includes a first needle drive including a first sample needle configured to extract the sample from the sample-vial and deliver the sample to the liquid chromatography column, and a first syringe in communication with the first sample needle configured to meter extraction of the sample from the sample-vial. The sample manager further includes a sample automation system that includes a second needle drive including a second sample needle configured to add a volume of reagent to the sample-vial.

A liquid chromatography system includes a solvent delivery system, a sample manager including a sample delivery system in fluidic communication with the solvent delivery system, the sample delivery system configured to inject a sample from a sample-vial into a chromatographic flow stream, a liquid chromatography column located downstream from the sample delivery system, and a detector located downstream from the liquid chromatography column. The sample delivery system further includes a first needle drive including a first sample needle configured to extract the sample from the sample-vial and deliver the sample to the liquid chromatography column, and a first syringe in communication with the first sample needle configured to meter extraction of the sample from the sample-vial. The sample manager further includes a sample automation system that includes a second needle drive including a second sample needle configured to add a volume of reagent to the sample-vial.

An automatic analyzer includes: a diluted sample holding unit configured to hold dilution containers into which a diluted sample is dispensed; a reaction container holding unit configured to hold reaction containers; a dispensing device configured to dispense the diluted sample from the dilution containers to the reaction containers; a measuring unit configured to perform optical measurement of the diluted sample reacted with reagents corresponding to test items in the reaction containers; a storage unit configured to store information on the diluted sample associated with each of the dilution containers; and a dispensing control unit. The dispensing control unit extracts a dilution container for collecting the diluted sample for retest by searching for the information on the diluted sample stored in the storage unit, and causes the dispensing device to perform a retest dispensing process.

Provided herein, in some embodiments, are compositions and methods for producing a molecular expression map of a biological sample using Deterministic Barcoding in Tissue for spatial omics sequencing (DBiT-seq).

A pipette module 10 has a pipette-module frame 12 attachable to the z-axis frame 120 of a liquid handling system 100. A translatory-motion frame 14 attached to the pipette-module frame 12 is movable with respect thereto by a motor 16. A pneumatic aspirator assembly 18 including a cylinder 20, tube 24, tube tip 26 and pressure sensor 28 is attached to the translatory-motion frame 14. A piston 22 disposed in the cylinder 20 is fixedly attached to the frame 12. A controller 30 for the pipette module 10 has a liquid surface detection mode which enables a pressure feedback control algorithm causing the motor 16 to move the translatory-motion frame 14 in a z-axis translator motion until a change in a pressure in the tip 26 as sensed by the pressure sensor 28 indicates that the tip 26 has made contact with the liquid surface 110.